3-[3-(2-benzyloxy-1-(benzyloxymethyl)ethoxy)-2-(2-benzyloxy-1-(benzyloxymethyl)ethoxymethyl)propoxy]-2-[3-(2-benzyloxy-1-(benzyloxymethyl)ethoxy)-2-(2-benzyloxy-1-(benzyloxymethyl)ethoxymethyl)propoxymethyl]propene | 219744-40-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 3-[3-(2-benzyloxy-1-(benzyloxymethyl)ethoxy)-2-(2-benzyloxy-1-(benzyloxymethyl)ethoxymethyl)propoxy]-2-[3-(2-benzyloxy-1-(benzyloxymethyl)ethoxy)-2-(2-benzyloxy-1-(benzyloxymethyl)ethoxymethyl)propoxymethyl]propene
• CAS: 219744-40-8
• 化学式: C₈₀H₉₆O₁₄
• 分子量: 1281.63
• InChiKey: XRNZZGMUUZEBGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.08
• 重原子数：
  94.0
• 可旋转键数：
  52.0
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  129.22
• 氢给体数：
  0.0
• 氢受体数：
  14.0

反应信息

• 作为反应物：
  描述：

  3-[3-(2-benzyloxy-1-(benzyloxymethyl)ethoxy)-2-(2-benzyloxy-1-(benzyloxymethyl)ethoxymethyl)propoxy]-2-[3-(2-benzyloxy-1-(benzyloxymethyl)ethoxy)-2-(2-benzyloxy-1-(benzyloxymethyl)ethoxymethyl)propoxymethyl]propene 在 三氟化硼四氢呋喃络合物 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 9.5h， 生成
  参考文献：
  名称：

  Amphiphilic polyether branched molecules to increase the circulation time of cationic particles

  摘要：

  The preparation, physicochemical and biological properties of amphiphilic polyether branched molecules is described. These 'bunch shaped' molecules when inserted into cationic liposomes/DNA complexes have shown efficient surface charge shielding. As a consequence they efficiently inhibited the non specific interactions with blood components and significantly enhanced circulation time of the particles in the blood track. Formulations containing these molecules compared positively with those containing PEG lipids, providing a 5-fold increase in circulation time. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.02.037
• 作为产物：
  描述：

  1,3-双(苄氧基)-2-丙醇 在 氢氧化钾 、 三氟化硼四氢呋喃络合物 、 18-冠醚-6 作用下， 以 四氢呋喃 为溶剂， 反应 9.5h， 生成 3-[3-(2-benzyloxy-1-(benzyloxymethyl)ethoxy)-2-(2-benzyloxy-1-(benzyloxymethyl)ethoxymethyl)propoxy]-2-[3-(2-benzyloxy-1-(benzyloxymethyl)ethoxy)-2-(2-benzyloxy-1-(benzyloxymethyl)ethoxymethyl)propoxymethyl]propene
  参考文献：
  名称：

  Amphiphilic polyether branched molecules to increase the circulation time of cationic particles

  摘要：

  The preparation, physicochemical and biological properties of amphiphilic polyether branched molecules is described. These 'bunch shaped' molecules when inserted into cationic liposomes/DNA complexes have shown efficient surface charge shielding. As a consequence they efficiently inhibited the non specific interactions with blood components and significantly enhanced circulation time of the particles in the blood track. Formulations containing these molecules compared positively with those containing PEG lipids, providing a 5-fold increase in circulation time. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.02.037

文献信息

• Synthesis and Surface Functionalization of Aliphatic Polyether Dendrons
  作者：Scott M. Grayson、Jean M. J. Fréchet

  DOI：10.1021/ja001903v

  日期：2000.10.1

  The convergent synthesis and surface modification of a novel family of aliphatic polyether dendrons is described. The synthesis utilizes methallyl dichloride as the monomeric building block along with peripheral benzyl ether and ketal protected hydroxy functionalities. The allylic nature of the electrophilic moieties of methallyl dichloride facilitates their nucleophilic displacement by 2 equiv of

  描述了一种新型脂肪族聚醚树突的聚合合成和表面改性。该合成使用二甲代烯丙基二氯作为单体结构单元以及外围苄醚和缩酮保护的羟基官能团。甲代烯丙基二氯的亲电部分的烯丙基性质促进了它们被 2 当量的适当末端醇基团的亲核置换。在偶联步骤中发挥其活化功能后，烯烃焦点可以通过硼氢化 - 氧化有效地转化为伯醇，导致亲核试剂，然后可以再次偶联到额外的单体上。这些偶联和激活步骤的重复提供了更高代的树突。
• A Convergent Route to Novel Aliphatic Polyether Dendrimers
  作者：Manikandan Jayaraman、Jean M. J. Fréchet

  DOI：10.1021/ja983229b

  日期：1998.12.1