4-amino-2-bromobenzohydrazide | 98280-16-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-amino-2-bromobenzohydrazide
• 英文别名: 4-amino-2-bromo-benzoic acid hydrazide；4-Amino-2-brom-benzoesaeure-hydrazid
• CAS: 98280-16-1
• 化学式: C₇H₈BrN₃O
• 分子量: 230.064
• InChiKey: LBXVLOGSUCFRBC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.63
• 重原子数：
  12.0
• 可旋转键数：
  1.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  81.14
• 氢给体数：
  3.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  4-amino-2-bromobenzohydrazide 、 水杨醛 生成 4-amino-2-bromo-benzoic acid salicylidenehydrazide
  参考文献：
  名称：

  Stoicescu-Crivetz; Mandasescu, Academia Republicii Populare Romine, Baza de Cercetari Stiintifice, Timisoara, Studii si Cercetari, Stiinte Chimice, 1956, vol. 4, p. 175,180

  摘要：

  DOI：
• 作为产物：
  描述：

  2-溴-4-硝基苯甲酸甲酯 在 一水合肼 作用下， 生成 4-amino-2-bromobenzohydrazide
  参考文献：
  名称：

  Stoicescu-Crivetz; Mandasescu, Academia Republicii Populare Romine, Baza de Cercetari Stiintifice, Timisoara, Studii si Cercetari, Stiinte Chimice, 1956, vol. 4, p. 175,179

  摘要：

  DOI：

文献信息

• Biological evaluation and molecular docking studies of 4-aminobenzohydrazide derivatives as cholinesterase inhibitors
  作者：Zuleyha Almaz、Aykut Oztekin、Ayse Tan、Hasan Ozdemir

  DOI：10.1016/j.molstruc.2021.130918

  日期：2021.11

  (AChE) and butyrylcholinesterase (BChE) enzymes have emerged as an encouraging approach in the treatment of dementia and remission of symptoms of Alzheimer's disease. Therefore, inhibition of cholinesterases is one of the main targets by researchers. Benzohydrazides are biologically active compounds and have various pharmacological effects, bearing these in mind, we investigated the inhibitory effects

  如今，抑制乙酰胆碱酯酶 (AChE) 和丁酰胆碱酯酶 (BChE) 已成为治疗痴呆症和缓解阿尔茨海默病症状的一种令人鼓舞的方法。因此，抑制胆碱酯酶是研究人员的主要目标之一。苯甲酰肼是生物活性化合物，具有多种药理作用，考虑到这些，我们研究了一些单或双取代的 4-氨基苯甲酰肼衍生物(1a-11a)对 AChE 和 BChE 的抑制作用。为此，我们研究了这些分子对 AChE 和 BChE 酶的抑制作用（IC 50、K i值和抑制类型）。根据结果​​，化合物3a显示出有效的 AChE 和 BChE 抑制（IC 50  = 0.59 和 0.15 μM）。计算了对 AChE 和 BChE 显示出最佳抑制效果的化合物（3a、4a和8a）的 K i值，这些值的范围为 0.10 ± 0.04 至 5.10 ± 2.14 μM。为了确定具有强抑制作用的化合物3a、4a和8a的两种酶的活性位点的可能结合机制，
• Purification of peroxidase enzyme from radish species in fast and high yield with affinity chromatography technique
  作者：Aykut Oztekin、Zuleyha Almaz、Serpil Gerni、Deniz Erel、Seyma Mehtap Kocak、Mehmet Emin Sengül、Hasan Ozdemir

  DOI：10.1016/j.jchromb.2019.03.035

  日期：2019.5

  In this study, an effective single step affinity method is presented for purifying plant peroxidase (POD) enzymes from radish species. This method make possible to purify the enzymes in high yield and purity. Briefly, 10 different 4-amino benzohydrazide derivatives were synthesized and identified as new competitive POD inhibitors. Then, these derivatives were coupled to Sepharose 4B-L-Tyrosine support matrix by diazotization to form the affinity gels. Purification factors were recorded as 54.8% yield - 665-fold, 33.8% yield - 613-fold, 22.7% yield - 595-fold, 34.4% yield 781-fold, 40.9% yield - 282-fold for turnip (T-POD), black radish (BR-POD), daikon (D-POD), sweet radish (SR-POD) and kohlrabi radish, (KR-POD), respectively. It has also been shown that the affinity gels, which prepared using the 4-amino 3-bromo benzohydrazide and 4-amino 2-nitro benzohydrazide molecules, capable to purify all radish species POD enzymes in high purity and yield.
• Stoicescu-Crivetz; Mandasescu, Academia Republicii Populare Romine, Baza de Cercetari Stiintifice, Timisoara, Studii si Cercetari, Stiinte Chimice, 1956, vol. 4, p. 175,179
  作者：Stoicescu-Crivetz、Mandasescu

  DOI：——

  日期：——
• Stoicescu-Crivetz; Mandasescu, Academia Republicii Populare Romine, Baza de Cercetari Stiintifice, Timisoara, Studii si Cercetari, Stiinte Chimice, 1956, vol. 4, p. 175,180
  作者：Stoicescu-Crivetz、Mandasescu

  DOI：——

  日期：——