5-(Phenylmethyl)-3a,6a-dihydro-1-methylpyrrolo<3,4-d>-1,2,3-triazole-4,6(1H,5H)-dione | 120566-60-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-(Phenylmethyl)-3a,6a-dihydro-1-methylpyrrolo<3,4-d>-1,2,3-triazole-4,6(1H,5H)-dione
• 英文别名: 5-Benzyl-3-methyl-3a,6a-dihydropyrrolo[3,4-d]triazole-4,6-dione
• CAS: 120566-60-1
• 化学式: C₁₂H₁₂N₄O₂
• 分子量: 244.253
• InChiKey: RTJRIKYEPBAFNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  65.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-(Phenylmethyl)-3a,6a-dihydro-1-methylpyrrolo<3,4-d>-1,2,3-triazole-4,6(1H,5H)-dione 以 1,4-二氧六环 为溶剂， 以89%的产率得到6-Methyl-3-(phenylmethyl)-3,6-diazabicyclo<3.1.0>hexane-2,4-dione
  参考文献：
  名称：

  一种通过光化学生成的偶氮甲碱碘化物的1,3-偶极环加成反应制得萘啶霉素和喹诺霉素的3,8-二氮杂双环[3.2.1]辛烷部分的方法。

  摘要：

  提出了一种有吸引力的策略，用于构建目标1和2的3,8-二氮杂双环[3.2.1]辛烷部分，涉及光化学生成的甲亚胺基团的1,3-偶极环加成。

  DOI：

  10.1016/0040-4039(88)85283-3
• 作为产物：
  描述：

  N-苯基马来酸 以 甲苯 为溶剂， 生成 5-(Phenylmethyl)-3a,6a-dihydro-1-methylpyrrolo<3,4-d>-1,2,3-triazole-4,6(1H,5H)-dione
  参考文献：
  名称：

  一种通过光化学生成的偶氮甲碱碘化物的1,3-偶极环加成反应制得萘啶霉素和喹诺霉素的3,8-二氮杂双环[3.2.1]辛烷部分的方法。

  摘要：

  提出了一种有吸引力的策略，用于构建目标1和2的3,8-二氮杂双环[3.2.1]辛烷部分，涉及光化学生成的甲亚胺基团的1,3-偶极环加成。

  DOI：

  10.1016/0040-4039(88)85283-3

文献信息

• An approach to the 3,8-diazabicyclo[3.2.1]octane moiety of naphthyridinomycin and quinocarcin via 1,3-dipolar cycloaddition of photochemically generated azomethine ylides.
  作者：Philip Garner、K. Sunitha、T. Shanthilal

  DOI：10.1016/0040-4039(88)85283-3

  日期：1988.1

  An attractive strategy for construction of the 3,8-diazabicyclo[3.2.1]octane moiety of targets 1 and 2 involving the 1,3-dipolar cycloaddition of photochemically generated azomethine ylides is presented.

  提出了一种有吸引力的策略，用于构建目标1和2的3,8-二氮杂双环[3.2.1]辛烷部分，涉及光化学生成的甲亚胺基团的1,3-偶极环加成。
• GARNER, PHILIP;SUNITHA, K.;SHANTHILAL, T., TETERAHEDRON LETT., 29,(1988) N 29, C. 3525-3528
  作者：GARNER, PHILIP、SUNITHA, K.、SHANTHILAL, T.

  DOI：——

  日期：——
• Development of an asymmetric approach to the 3,8-diazabicyclo[3.2.1]octane moiety of quinocarcin via intramolecular 1,3-dipolar cycloadditions of photochemically generated azomethine ylides
  作者：Philip Garner、Wen Bin Ho、Sunitha K. Grandhee、Wiley J. Youngs、Vance O. Kennedy

  DOI：10.1021/jo00020a035

  日期：1991.9

  Exploratory work culminating in an enantioselective approach to the DNA-reactive alkaloid quinocarcin (1) is detailed. The key step involves auxiliary-controlled dipolar cycloaddition between photochemically generated azomethine ylides such as 11 and Oppolzer's chiral acryloyl sultam (-)-32 to assemble the 6-exo-substituted 3,8-diazabicyclo[3.2.1]octane core of 1. The synthetic sequence begins with condensation of the benzylamines 3 and maleic anhydride to give the N-alkylated maleimides 6. Triazoline formation (MeN3) followed by photolytic (lambda > 3000 angstrom) extrusion of nitrogen leads to the corresponding aziridines 10. Upon irradiation at 2537 angstrom, these aziridines undergo electrocyclic ring-opening to give azomethine ylides 11, which can be trapped with (-)-32 to give the 6-exo-substituted cycloadduct 33 (diastereoselectivity, ds > 25:1). These results stand in sharp contrast to cycloadditions of 11 with (achiral and chiral) acrylate ester dipolarophiles as well as acrylonitrile, which proceed with no appreciable facial selectivity. The expected re-face selectivity of (-)-32 was confirmed in one case by X-ray crystallographic analysis of endo-adduct 35a. Removal (and recovery) of the chiral sultam auxiliary can be effected by titanium (IV)-mediated alcoholysis to give ester derivatives of the cycloadducts.