tris[4-[N-[2-(5-methoxy-2-methyl-1H-indol-3-yl)acetyl]-α-L-glutamyl]aminophenyl]methane | 378800-64-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tris[4-[N-[2-(5-methoxy-2-methyl-1H-indol-3-yl)acetyl]-α-L-glutamyl]aminophenyl]methane
• 英文别名: (4S)-5-[4-[bis[4-[[(2S)-4-carboxy-2-[[2-(5-methoxy-2-methyl-1H-indol-3-yl)acetyl]amino]butanoyl]amino]phenyl]methyl]anilino]-4-[[2-(5-methoxy-2-methyl-1H-indol-3-yl)acetyl]amino]-5-oxopentanoic acid
• CAS: 378800-64-7
• 化学式: C₇₀H₇₃N₉O₁₅
• 分子量: 1280.4
• InChiKey: GWSFNHNYDDUZKL-RATTXREYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  94
• 可旋转键数：
  30
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  362
• 氢给体数：
  12
• 氢受体数：
  15

文献信息

• Compounds exhibiting thrombopoietin-like activities
  申请人：——

  公开号：US20030162724A1

  公开（公告）日：2003-08-28

  The compounds of the invention are compounds represented by the following general formula (1): 1 wherein E represents one selected from the group consisting of a methylidyne group and a nitrilo group, R 1 represents one selected from the group consisting of optionally substituted aryl groups and optionally substituted heteroaryl groups, R 2 represents one selected from the group consisting of a hydrogen atom and alkyl groups, W 1 represents an amino acid residue, A represents one selected from the group consisting of a carbonyl group and a sulfonyl group, X 1 represents one selected from the group consisting of optionally substituted alkylene groups and optionally substituted alkenylene groups, and p represents 0 or 1; and their pharmacologically acceptable salts, which exhibit thrombopoietin-like activity.

  本发明的化合物是由以下一般式（1）表示的化合物：其中E代表从甲基亚基团和硝基亚基团组成的群体中选择的一种，R1代表从可选择的取代芳基和可选择的取代杂环烷基组成的群体中选择的一种，R2代表从氢原子和烷基组成的群体中选择的一种，W1代表氨基酸残基，A代表从羰基和磺酰基组成的群体中选择的一种，X1代表从可选择的取代烷基烯基团和可选择的取代烯基烷基团组成的群体中选择的一种，p代表0或1；以及它们的药理学上可接受的盐，具有类似于血小板生成素的活性。
• COMPOUNDS EXHIBITING THROMBOPOIETIN-LIKE ACTIVITIES
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：EP1291341A1

  公开（公告）日：2003-03-12

  The compounds of the invention are compounds represented by the following general formula (1): wherein E represents one selected from the group consisting of a methylidyne group and a nitrilo group, R1 represents one selected from the group consisting of optionally substituted aryl groups and optionally substituted heteroaryl groups, R2 represents one selected from the group consisting of a hydrogen atom and alkyl groups, W1 represents an amino acid residue, A represents one selected from the group consisting of a carbonyl group and a sulfonyl group, X1 represents one selected from the group consisting of optionally substituted alkylene groups and optionally substituted alkenylene groups, and p represents 0 or 1; and their pharmacologically acceptable salts, which exhibit thrombopoietin-like activity.

  本发明的化合物是由以下通式（1）表示的化合物： 其中 E 代表选自由甲炔基和亚硝基组成的组，R1 代表选自由取代芳基和选自由取代杂芳基组成的组，R2 代表选自由氢原子和烷基组成的组，W1 代表氨基酸残基，A 代表选自由羰基和磺酰基组成的组，X1 代表选自由取代亚烷基和选自由取代烯基组成的组，p 代表 0 或 1；及其药理上可接受的盐类，这些盐类具有类似血小板生成素的活性。
• US6887890B2
  申请人：——

  公开号：US6887890B2

  公开（公告）日：2005-05-03