3-trimethylgermylpropionate of N-(2-(2-hydroxyethoxy)ethyl)-4-aza-9-crown-3 | 397246-60-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-trimethylgermylpropionate of N-(2-(2-hydroxyethoxy)ethyl)-4-aza-9-crown-3
• 英文别名: 2-[2-(1,4,7-Dioxazonan-7-yl)ethoxy]ethyl 3-trimethylgermylpropanoate
• CAS: 397246-60-5
• 化学式: C₁₆H₃₃GeNO₅
• 分子量: 392.032
• InChiKey: SXXIPHPLVZXRPN-UHFFFAOYSA-N

物化性质

• 沸点：
  444.6±55.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.62
• 重原子数：
  23
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  57.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-(trimethylgermyl)propanoic acid 、 N-[2-(2-hydroxyethoxy)ethyl]-4-aza-9-crown-3 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 氯仿 为溶剂， 以70.7%的产率得到3-trimethylgermylpropionate of N-(2-(2-hydroxyethoxy)ethyl)-4-aza-9-crown-3
  参考文献：
  名称：

  Synthesis of azacrown ethers modified with side-chains containing germanium

  摘要：

  The reaction between ethanolamine (4) and tri- or tetraethylene tosylate (5) and (13) gave 9- and 12-membered monoazacrowns with a -CH2CH2OH residue on nitrogen, A-OH and B-OH, together with 18- and 24-membered diazacrown ethers with the same substituent on nitrogen, E-OH and F-OH. If 2-(2-aminoethoxy)ethanol (12) was used in the reaction described above, instead of 4, the final products, G-OH and H-OH, and K-OH and L-OH, have a longer side chain, -CH2CH2OCH2CH2OH, on nitrogen (Route 1). A series of reactions involving bromoethanol (6) and diethanolamine (9) formed, with 5 or 13, 18- and 24-membered monoazacrowns with the shorter substituent as described above, a 15-membered monoazacrown ether C-OH and an 18-membered D-OH. If 2-(2-chloroethoxy)ethanol (14) is used instead of 6, I-OH and J-OH are obtained (Route 2'). All these hydroxy azacrown ethers were made to react with 3-trimethylgermylpropionic acid (18) to give the corresponding germanium-containing A-L. A preliminary investigation was carried out on the cation transport capability of these germanium-containing azacrown ethers to observe whether germanium might enhance their cation transporting capability. (C) 2001 Published by Elsevier Science B.V.

  DOI：

  10.1016/s0022-328x(01)01054-3