uridine-5'-monophosphate sodium | 3106-18-1

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 英文名称: uridine-5'-monophosphate sodium
• 英文别名: Uridine 5'-phosphate；uridine monophosphate；uridine monophosphate sodium；sodium;1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-olate
• CAS: 3106-18-1
• 化学式: C₉H₁₂N₂O₉P*Na
• 分子量: 346.166
• InChiKey: WHRWYTJLFJEXDD-IAIGYFSYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -6.36
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  169
• 氢给体数：
  4
• 氢受体数：
  9

安全信息

• 危险性防范说明：
  P261,P280,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H332,H335

反应信息

• 作为反应物：
  描述：

  uridine-5'-monophosphate sodium 在 水 、 三乙胺 作用下， 以 水 为溶剂， 反应 49.33h， 生成 阿糖尿苷
  参考文献：
  名称：

  Reaction of uridine and uridine 5'-phosphate with diiminosuccinonitrile and cyanogen bromide in aqueous solution. Direct synthesis of the 2,2'-anhydronucleoside linkage at 2.degree.C

  摘要：

  DOI：

  10.1021/jo00186a008

文献信息

• Sulfonyl Imidazolium Salts as Reagents for the Rapid and Efficient Synthesis of Nucleoside Polyphosphates and Their Conjugates
  作者：Samy Mohamady、Ahmed Desoky、Scott D. Taylor

  DOI：10.1021/ol203178k

  日期：2012.1.6

  A procedure for the synthesis of nucleoside polyphosphates and their conjugates using sulfonylimidazolium salts as key reagents is described. The procedure is rapid and high yielding, does not require prior protection and subsequent deprotection of the donors or acceptors, and can be used to activate nucleoside mono-, di- and triphosphates, and a wide variety of acceptors and donors can be used.

  描述了使用磺酰亚胺咪唑鎓盐作为关键试剂合成核苷多磷酸盐及其缀合物的方法。该方法是快速且高产率的，不需要供体或受体的事先保护和随后的脱保护，并且可以用于活化核苷单，二和三磷酸，并且可以使用各种各样的受体和供体。
• Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5′-polyphosphates
  作者：William Pendergast、Benjamin R Yerxa、James G Douglass、Sammy R Shaver、Robert W Dougherty、Catherine C Redick、Ingrid F Sims、Janet L Rideout

  DOI：10.1016/s0960-894x(00)00612-0

  日期：2001.1

  A series of dinucleoside 5-polyphosphates UpnU (n = 2-7) was synthesized. Their relative potencies as agonists at the G-protein-coupled receptors P2Y1, P2Y2, P2Y4, and P2Y6 were determined by intracellular calcium measurements using fluorescent imaging techniques. The correlation of phosphate chain length to activities at these receptors is discussed.

  合成了一系列的二核苷5-聚磷酸盐UpnU（n = 2-7）。通过使用荧光成像技术通过细胞内钙测量来确定它们在G蛋白偶联受体P2Y1，P2Y2，P2Y4和P2Y6上作为激动剂的相对效能。讨论了磷酸链长度与这些受体活性的相关性。
• Efficient synthesis of cytidine diphosphate diacylglycerol: A crucial precursor of glycerophospholipids biosynthesis
  作者：Yuki Kitaura、Rina Ueshima、Kanae Sano、Takashi Kikuma、Yoichi Takeda

  DOI：10.1016/j.tetlet.2023.154781

  日期：2023.11

  glycerophospholipids comprising lipid membranes. However, achieving efficient condensation of phosphatidic acid with cytidine monophosphate (CMP) in the chemical synthesis of CDP-DAG remains challenging. This study demonstrated the efficient synthesis of liponucleotides using sulfonyl imidazolium triflate as an activator. The pyridinium salts of CMP and phosphatidic acid were rapidly activated with sulfonylimidazolium

  胞苷二磷酸二酰基甘油 (CDP-DAG) 是形成多种构成脂质膜的甘油磷脂的重要前体。然而，在 CDP-DAG 的化学合成中实现磷脂酸与胞苷单磷酸 (CMP) 的有效缩合仍然具有挑战性。这项研究证明了使用磺酰咪唑鎓三氟甲磺酸盐作为活化剂可以有效合成脂核苷酸。这CMP 和磷脂酸的吡啶鎓盐被磺酰咪唑鎓盐快速活化，以高产率产生 CDP-DAG。因此，磺酰咪唑鎓盐是合成CDP-DAG的有用活化剂。这种方法有助于开发重要工具来阐明甘油磷脂（细胞膜的重要成分）的生物合成和调节机制。这项研究为脂核苷酸（例如 CDP-DAG）的合成及其在理解细胞膜形成方面的重要性提供了宝贵的见解。
• COMPOSITION FOR CELL PROLIFERATION
  申请人：Otsuka Pharmaceutical Company, Limited

  公开号：EP1498101A1

  公开（公告）日：2005-01-19

  The present invention provides a method for effectively exerting a cell proliferation promoting effect of a purine nucleic acid-related substance. The present invention provides a composition for cell proliferation containing a purine nucleic acid-related substance and a pyrimidine nucleic acid-related substance. Further, the present invention provides a method for potentiating the cell proliferation promoting effect of the purine nucleic acid-related substance by using the purine nucleic acid-related substance in combination with the pyrimidine nucleic acid-related substance. Still further, the present invention provides a method for promoting cell proliferation, where the method comprising applying purine nucleic acid-related substance in combination with the pyrimidine nucleic acid-related substance to the skin or mucosa.

  本发明提供了一种有效发挥嘌呤核酸相关物质促进细胞增殖作用的方法。本发明提供了一种含有嘌呤核酸相关物质和嘧啶核酸相关物质的细胞增殖组合物。此外，本发明还提供了一种通过将嘌呤核酸相关物质与嘧啶核酸相关物质结合使用来增强嘌呤核酸相关物质促进细胞增殖效果的方法。更进一步，本发明提供了一种促进细胞增殖的方法，该方法包括将嘌呤核酸相关物质与嘧啶核酸相关物质结合应用于皮肤或粘膜。
• COMPOSITION FOR PROMOTING COLLAGEN PRODUCTION
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP1671618A1

  公开（公告）日：2006-06-21

  The invention provides a composition for promoting collagen production, and more specifically, provides a composition capable of promoting collagen production in human dermis. Further, the invention provides a method for promoting collagen production. The invention provides a composition for promoting collagen production containing a purine nucleic acid-related substance as an active ingredient as well as a composition for promoting collagen production containing a purine nucleic acid-related substance and a pyrimidine nucleic acid-related substance. The method for promoting collagen production of the invention comprises applying a purine nucleic acid-related substance alone or in combination with a pyrimidine nucleic acid-related substance to the skin.

  本发明提供了一种促进胶原蛋白生成的组合物，更具体地说，提供了一种能够促进人体真皮层胶原蛋白生成的组合物。此外，本发明还提供了一种促进胶原蛋白生成的方法。本发明提供了一种含有嘌呤核酸相关物质作为活性成分的促进胶原蛋白生成的组合物，以及一种含有嘌呤核酸相关物质和嘧啶核酸相关物质的促进胶原蛋白生成的组合物。本发明促进胶原蛋白生成的方法包括将嘌呤核酸相关物质单独或与嘧啶核酸相关物质结合应用于皮肤。