SDAD (NHS-SS-Diazirine) | 1253202-38-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: SDAD (NHS-SS-Diazirine)
• 英文别名: (2,5-dioxopyrrolidin-1-yl) 3-[2-[3-(3-methyldiazirin-3-yl)propanoylamino]ethyldisulfanyl]propanoate
• CAS: 1253202-38-8
• 化学式: C₁₄H₂₀N₄O₅S₂
• 分子量: 388.469
• InChiKey: NLPWBELUEANJAT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  25
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  168
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  4'-氨基甲基-4,5'，8-三甲基补骨脂素 、 SDAD (NHS-SS-Diazirine) 生成
  参考文献：
  名称：

  BIFUNCTIONAL PHOTOCROSSLINKING PROBES FOR COVALENT CAPTURE OF PROTEIN-NUCLEIC ACID COMPLEXES IN CELLS

  摘要：

  A new class of molecular probes is provided for real, efficient, stable, and selective capture of protein-nucleic acid complexes inside cells. The molecular probes have a nucleic acid-binding functional group and a photo-reactive diazirine based functional group, separated by a linker of a selected length or with a multi-arm core, thereby generating a photocrosslink between nucleic acids and proteins in close proximity. This is useful in various chromatin research, including the study of interactions between transcription factors and DNA.

  公开号：

  WO2024015963A2

文献信息

• BOVINE SERUM ALBUMIN (BSA)-DIAZIRINE, METHOD OF FORMING BSA-DIAZIRINE, AND METHOD OF SELECTIVELY FIXING BIOMATERIAL USING BSA-DIAZIRINE OF PHOTO-REACTIVE TYPE
  申请人：KIM Wan Joong

  公开号：US20120288640A1

  公开（公告）日：2012-11-15

  The present invention provides bovine serum albumin (BSA)-diazirine, a method of forming BSA-diazirine, and a method of selectively fixing biomaterial using thereof. The bovine serum albumin-diazirine may function as a blocker which prevents the non-specific binding, as well as a linker, which links the solid support and the biomaterial by photoreaction (by UV irradiation). Therefore, by using the bovine serum albumin-diazirine, it is possible to selectively fix the biomaterial.