tert-butyl 1-(methoxycarbonyl)buta-1,3-dienylcarbamate | 1000986-30-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl 1-(methoxycarbonyl)buta-1,3-dienylcarbamate
• 英文别名: Methyl 2-[(2-methylpropan-2-yl)oxycarbonylamino]penta-2,4-dienoate
• CAS: 1000986-30-0
• 化学式: C₁₁H₁₇NO₄
• 分子量: 227.26
• InChiKey: XMNJYXDSSCSUGD-UHFFFAOYSA-N

物化性质

• 沸点：
  311.3±34.0 °C(predicted)
• 密度：
  1.059±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (2S)-methyl 2-tert-butoxycarbonylamino-3-fluoro-pent-4-enoate 在 lithium hydroxide 作用下， 生成 tert-butyl 1-(methoxycarbonyl)buta-1,3-dienylcarbamate
  参考文献：
  名称：

  New enantiomerically enriched amino allyl- and allenylsilanes derived from naturally occurring amino acids

  摘要：

  Some enantiomerically enriched Z-amino allylsilanes and allenylsilanes have been obtained selectively through the synthetic elaboration of naturally occurring amino acids. Fluorodesilylation with Selectfluor (R) has been proved as an easy way for preparing allylic fluorides bearing an amino or an amino acid moiety on the lateral chain. In particular, a new unsaturated fluorinated amino acid has been obtained, albeit as a diastereomeric mixture. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.12.025

文献信息

• Synthesis of optically active α-(allenyl)- and α-substituted-α-(allenyl)glycines
  作者：Takuya Okada、Naoko Oda、Hiroyuki Suzuki、Kazuhiko Sakaguchi、Yasufumi Ohfune

  DOI：10.1016/j.tetlet.2010.05.042

  日期：2010.7

  The synthesis of various types of optically active α-(allenylsilane-containing)glycines via a chirality-transferring ester-enolate Claisen rearrangement of α-acyloxy-α-alkynylsilanes is described. The conversion of the rearranged products into the optically active silicon-free α-(allenyl)- and α-substituted-α-(allenyl)glycines was achieved by the removal of the Me2PhSi- or TMS group from the allene

  描述了通过α-酰氧基-α-炔基硅烷的手性转移酯-烯醇式克莱森重排合成各种类型的旋光性α-（含烯丙基硅烷的）甘氨酸。通过从丙二烯末端除去Me 2 PhSi-或TMS基团，将重排产物转化为旋光的无硅的α-（烯丙基）-和α-取代的-α-（烯基）甘氨酸。