(S)-tert-butyl 2-((E)-(((S)-tert-butylsulfinyl)imino)methyl)pyrrolidine-1-carboxylate | 1224300-78-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (S)-tert-butyl 2-((E)-(((S)-tert-butylsulfinyl)imino)methyl)pyrrolidine-1-carboxylate
• 英文别名: tert-butyl (S)-2-((E)-((S)-tert-butylsulfinylimino)-methyl)pyrrolidine-1-carboxylate；tert-butyl (2S)-2-[(E)-[(S)-tert-butylsulfinyl]iminomethyl]pyrrolidine-1-carboxylate
• CAS: 1224300-78-0
• 化学式: C₁₄H₂₆N₂O₃S
• 分子量: 302.438
• InChiKey: AAQKDLKIOANCTM-KPVGCOOLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  78.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-溴-n-丙基-1-乙氧基乙醚 、 (S)-tert-butyl 2-((E)-(((S)-tert-butylsulfinyl)imino)methyl)pyrrolidine-1-carboxylate 在 magnesium 、 水 、 氯化铵 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 15.0h， 生成 C₂₁H₄₂N₂O₅S
  参考文献：
  名称：

  Short asymmetric synthesis of (S,S)-PDP using l-prolinol derivative as economic starting material

  摘要：

  (S,S)-PDP (5d) and its backbone (2S2'S)-bipyrioldine (1) have been extensively applied as the scaffold of various chiral ligands in catalytic asymmetric syntheses In this study, new short asymmetric syntheses of these two important C-2-symmetrical nitrogen heterocycles have been accomplished employing economically available t-prolinol derivative 10 as the starting material Excellent diastereoselectivity was achieved of the key Grignard addition to imine intermediate utilizing (S)-N-tert-butanesulfinamide as the chiral auxiliary (C) 2010 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tet.2010.02.048
• 作为产物：
  描述：

  (S)-N-Boc-吡咯烷-2-甲醛 N-(叔丁氧羰基)-L-脯氨醛 、 S-叔丁基亚磺酰胺 在 titanium(IV) tetraethanolate 作用下， 以 四氢呋喃 为溶剂， 以65%的产率得到(S)-tert-butyl 2-((E)-(((S)-tert-butylsulfinyl)imino)methyl)pyrrolidine-1-carboxylate
  参考文献：
  名称：

  Short asymmetric synthesis of (S,S)-PDP using l-prolinol derivative as economic starting material

  摘要：

  (S,S)-PDP (5d) and its backbone (2S2'S)-bipyrioldine (1) have been extensively applied as the scaffold of various chiral ligands in catalytic asymmetric syntheses In this study, new short asymmetric syntheses of these two important C-2-symmetrical nitrogen heterocycles have been accomplished employing economically available t-prolinol derivative 10 as the starting material Excellent diastereoselectivity was achieved of the key Grignard addition to imine intermediate utilizing (S)-N-tert-butanesulfinamide as the chiral auxiliary (C) 2010 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tet.2010.02.048

文献信息

• NOVEL MORPHOLINE DERIVATIVE OR SALT THEREOF
  申请人：FUJIFILM Corporation

  公开号：US20160168139A1

  公开（公告）日：2016-06-16

  There is provided a morpholine derivative represented by General Formula [1A] or a salt thereof. (In the formula, a ring A represents a ring represented by General Formula [I]; * represents a bonding position; Z 2 represents CH or the like; Z 1 represents CR 6 or the like; R 6 represents a hydrogen atom or the like; X 1 represents CHR 7 or the like; R 7 represents a hydrogen atom or the like; X 2 represents CH 2 or the like; R 1 and R 2 are the same as or different from each other, and each of R 1 and R 2 represents a hydrogen atom or the like; R 3 , R 4 , and R 5 are the same as or different from each other, and each of R 3 , R 4 , and R 5 represents a hydrogen atom, NR a R b , or the like; and each of R a and R b represents a hydrogen atom, a C 1-8 alkyl group which may have a substituent, or the like.)

  提供一种由通用式[1A]表示的吗啉衍生物或其盐。 （在该式中，环A代表由通用式[I]表示的环；*代表连接位置；Z 2 代表CH或类似物；Z 1 代表CR 6 或类似物；R 6 代表氢原子或类似物；X 1 代表CHR 7 或类似物；R 7 代表氢原子或类似物；X 2 代表CH 2 或类似物；R 1 和R 2 相同或不同，且R 1 和R 2 中的每一个代表氢原子或类似物；R 3 ，R 4 和R 5 相同或不同，且R 3 ，R 4 和R 5 中的每一个代表氢原子，NR a R b 或类似物；R a 和R b 中的每一个代表氢原子，可能具有取代基的C 1-8 烷基基团，或类似物。）
• US9586951B2
  申请人：——

  公开号：US9586951B2

  公开（公告）日：2017-03-07
• Short asymmetric synthesis of (S,S)-PDP using l-prolinol derivative as economic starting material
  作者：Xiao-Nan Song、Zhu-Jun Yao

  DOI：10.1016/j.tet.2010.02.048

  日期：2010.4

  (S,S)-PDP (5d) and its backbone (2S2'S)-bipyrioldine (1) have been extensively applied as the scaffold of various chiral ligands in catalytic asymmetric syntheses In this study, new short asymmetric syntheses of these two important C-2-symmetrical nitrogen heterocycles have been accomplished employing economically available t-prolinol derivative 10 as the starting material Excellent diastereoselectivity was achieved of the key Grignard addition to imine intermediate utilizing (S)-N-tert-butanesulfinamide as the chiral auxiliary (C) 2010 Elsevier Ltd All rights reserved