4-[2-(4-((pyrrolidin-1-yl)methyl)phenyl)pyridin-4-yl]-5-[6-methyl-pyridin-2-yl]-1,3-thiazol-2-ylamine | 656258-11-6

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 4-[2-(4-((pyrrolidin-1-yl)methyl)phenyl)pyridin-4-yl]-5-[6-methyl-pyridin-2-yl]-1,3-thiazol-2-ylamine
• 英文别名: 5-(6-Methylpyridin-2-yl)-4-[2-[4-(pyrrolidin-1-ylmethyl)phenyl]pyridin-4-yl]-1,3-thiazol-2-amine
• CAS: 656258-11-6
• 化学式: C₂₅H₂₅N₅S
• 分子量: 427.573
• InChiKey: DDFUHMHKNISXJH-UHFFFAOYSA-N

物化性质

• 沸点：
  581.7±50.0 °C(Predicted)
• 密度：
  1.251±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  96.2
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Compounds
  申请人：Dodic Nerina

  公开号：US20060004051A1

  公开（公告）日：2006-01-05

  The invention relates to novel aminothiazole derivatives which are inhibitors of the transforming growth factor, (“TGF”)-β signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase (“ALK”)-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.

  本发明涉及一种新型的氨基噻唑衍生物，该衍生物是转化生长因子（“TGF”）-β信号通路的抑制剂，特别是抑制TGF-β类型I或类激活素样激酶（“ALK”）-5受体对smad2或smad3的磷酸化，以及该衍生物的制备方法和在医学上的应用，具体地用于治疗和预防由该通路介导的疾病状态。
• Anti-fungal formulation of triterpene and essential oil
  申请人：Carlson M. Robert

  公开号：US20050014730A1

  公开（公告）日：2005-01-20

  The present invention provides for pharmaceutical compositions that includes a triterpene (e.g., betulin) and an essential oil (Vicks® Vapor Rub). The present invention also provides for a cosmetic formulation that includes a triterpene (e.g., betulin) and an essential oil (Vicks® Vapor Rub). The present invention also provides a method of treating a fungal infection that includes administering (e.g., topically applying) an effective amount of the pharmaceutical composition to the tissue afflicted with the fungal infection, or the tissue at risk of being afflicted with the fungal infection.

  本发明提供的药物组合物包括一种三萜（如白桦脂）和一种精油（Vicks® Vapor Rub）。本发明还提供了一种化妆品配方，其中包括一种三萜（如白桦脂素）和一种精油（Vicks® Vapor Rub）。本发明还提供了一种治疗真菌感染的方法，该方法包括将有效量的药物组合物施用于（如局部施用）受真菌感染的组织或有受真菌感染风险的组织。
• Compositions that include a triterpene and a carrier
  申请人：Krasutsky A. Pavel

  公开号：US20060003948A1

  公开（公告）日：2006-01-05

  The present invention provides for compositions that includes a triterpene (e.g., betulin) and a carrier (e.g., lanolin). The compositions are useful for skin care (e.g., as cosmetic formulations), and as therapeutic formulations, e.g., for treating topical fungal infections.

  本发明提供了包括三萜（如白桦脂）和载体（如羊毛脂）的组合物。这些组合物可用于皮肤护理（如化妆品配方）和治疗配方，如治疗局部真菌感染。
• COMPOUNDS
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1554275A2

  公开（公告）日：2005-07-20
• [EN] COMPOUNDS<br/>[FR] COMPOSES
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2004013134A2

  公开（公告）日：2004-02-12

  The invention relates to novel aminothiazole derivatives which are inhibitors of the transforming growth factor, ('TGF')-ß signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase ('ALK')-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.