[2-(2-{2-[2-(11-Acetylsulfanyl-undecyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid tert-butyl ester | 663171-38-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 硫代羧酸及其衍生物
• 英文名称: [2-(2-{2-[2-(11-Acetylsulfanyl-undecyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid tert-butyl ester
• CAS: 663171-38-8
• 化学式: C₂₇H₅₂O₈S
• 分子量: 536.771
• InChiKey: HLAWJZWXPNRKBN-UHFFFAOYSA-N

物化性质

• 沸点：
  581.8±40.0 °C(Predicted)
• 密度：
  1.030±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  36.0
• 可旋转键数：
  26.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  89.52
• 氢给体数：
  0.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  [2-(2-{2-[2-(11-Acetylsulfanyl-undecyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid tert-butyl ester 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 [2-(2-{2-[2-(11-Acetylsulfanyl-undecyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid
  参考文献：
  名称：

  Control of Protein Structure and Function through Surface Recognition by Tailored Nanoparticle Scaffolds

  摘要：

  Thioalkyl and thioalkylated oligo(ethylene glycol) (OEG) ligands with chain-end functionality were used to fabricate water-soluble CdSe nanoparticle scaffolds. Surface recognition of chymotrypsin (ChT) was achieved using these functionalized nanoparticle scaffolds, with three levels of interaction demonstrated: no interaction (OEG terminated with hydroxyl group), inhibition with denaturation (carboxylate-terminated thioalkyl ligands), and inhibition with retention of structure (carboxylate-terminated OEG). The latter process was reversible upon an increase in ionic strength, with essentially complete restoration of enzymatic activity.

  DOI：

  10.1021/ja037470o
• 作为产物：
  描述：

  溴乙酸叔丁酯 在 偶氮二异丁腈 、 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 8.17h， 生成 [2-(2-{2-[2-(11-Acetylsulfanyl-undecyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid tert-butyl ester
  参考文献：
  名称：

  Control of Protein Structure and Function through Surface Recognition by Tailored Nanoparticle Scaffolds

  摘要：

  Thioalkyl and thioalkylated oligo(ethylene glycol) (OEG) ligands with chain-end functionality were used to fabricate water-soluble CdSe nanoparticle scaffolds. Surface recognition of chymotrypsin (ChT) was achieved using these functionalized nanoparticle scaffolds, with three levels of interaction demonstrated: no interaction (OEG terminated with hydroxyl group), inhibition with denaturation (carboxylate-terminated thioalkyl ligands), and inhibition with retention of structure (carboxylate-terminated OEG). The latter process was reversible upon an increase in ionic strength, with essentially complete restoration of enzymatic activity.

  DOI：

  10.1021/ja037470o

文献信息

• Guided Assemblies of Ferritin Nanocages: Highly Ordered Arrays of Monodisperse Nanoscopic Elements
  作者：Yunxia Hu、Dian Chen、Soojin Park、Todd Emrick、Thomas P. Russell

  DOI：10.1002/adma.200903578

  日期：——

  High‐density arrays of highly ordered ferritin nanocages are fabricated through the guided assembly of thiol‐modified ferritin on prepatterned gold nanodots, which are prepared by block copolymer micelle lithography. One and only one ferritin nanocage is anchored to each gold nanodot, as confirmed by scanning electron and scanning force microscopy.

  高密度排列的高度有序的铁蛋白纳米笼是通过将硫醇修饰的铁蛋白引导组装在预先构图的金纳米点上而制成的，这些金点通过嵌段共聚物胶束光刻技术制备。如通过扫描电子和扫描力显微镜所证实的，将一个且仅有一个铁蛋白纳米笼固定在每个金纳米点上。