8-(2-phenoxy-ethoxy)-octan-1-ol | 1192596-60-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 8-(2-phenoxy-ethoxy)-octan-1-ol
• 英文别名: 8-(2-Phenoxyethoxy)octan-1-ol
• CAS: 1192596-60-3
• 化学式: C₁₆H₂₆O₃
• 分子量: 266.381
• InChiKey: XEENBYQKTPAJPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  19
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• 4-DIMETHYLAMINOBUTYRIC ACID DERIVATIVES
  申请人：Andjelkovic Mirjana

  公开号：US20090270505A1

  公开（公告）日：2009-10-29

  This invention relates to novel 4-dimethylaminobutyric acid derivatives of the formula wherein A 1 , A 2 , R 1 , m and n are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit carnitine palmitoyl transferase (CPT) activity, in particular CPT2 activity, and can be used as medicaments in methods for the treatment of diseases modulated by CPT2 inhibitors.

  这项发明涉及新颖的4-二甲基氨基丁酸衍生物，其化学式如下：其中A1、A2、R1、m和n的定义如描述和索赔中所述，以及其药学上可接受的盐。这些化合物抑制肉碱棕榈酰基转移酶（CPT）活性，特别是CPT2活性，并可用作药物治疗受CPT2抑制剂调节的疾病的方法中的药物。
• METHODS AND PROTEINS FOR THE PROPHYLACTIC AND/OR THERAPEUTIC TREATMENT OF THE FOUR SEROTYPES OF DENGUE VIRUS AND OTHER FLAVIVIRUSES
  申请人：CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA (CIGB)

  公开号：EP1958959A2

  公开（公告）日：2008-08-20

  The present invention is related to the field of the pharmaceutical industry, and describes a conserved area on the surface of the E protein that can be used for the development of wide-spectrum antiviral molecules to be employed in the prophylaxis and/or treatment of infections due to Dengue Virus serotypes 1-4 and other flaviviruses. The invention also covers chimeric proteins to be used as vaccines or as a prophylactic or therapeutic treatment against the four serotypes of Dengue Virus and other flaviviruses.

  本发明涉及制药工业领域，描述了 E 蛋白表面的一个保守区，该保守区可用于开发广谱抗 病毒分子，以预防和/或治疗登革病毒 1-4 血清型和其他黄病毒引起的感染。本发明还包括可用作疫苗或预防或治疗登革病毒四种血清型及其他黄病毒的嵌合蛋白。
• Methods and Proteins for the Prophylactic and/or Therapeutic Treatment of Four Serotypes of Dengue Virus and Other Flaviviruses
  申请人：Chinea Santiago Glay

  公开号：US20090312190A1

  公开（公告）日：2009-12-17

  The present invention is related to the field of the pharmaceutical industry, and describes a conserved area on the surface of the E protein that can be used for the development of wide-spectrum antiviral molecules to be employed in the prophylaxis and/or treatment of infections due to Dengue Virus serotypes 1-4 and other flaviviruses. The invention also covers chimeric proteins to be used as vaccines or as a prophylactic or therapeutic treatment against the four serotypes of Dengue Virus and other flaviviruses.
• US8344027B2
  申请人：——

  公开号：US8344027B2

  公开（公告）日：2013-01-01
• [EN] 4-DIMETHYLAMINOBUTYRIC ACID DERIVATIVES<br/>[FR] DÉRIVÉS D'ACIDE 4-DIMÉTHYLAMINOBUTYRIQUE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2009132978A1

  公开（公告）日：2009-11-05

  This invention relates to novel 4-dimethylaminobutyric acid derivatives of the formula (I) wherein A1, A2, R1, m and n are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit carnitine palmitoyl transferase (CPT) activity, in particular CPT2 activity, and can be used as medicaments.