β-<5-Fluor-uracilyl-(1)>-α-amino-propionsaeure | 33233-74-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: β-<5-Fluor-uracilyl-(1)>-α-amino-propionsaeure
• 英文别名: 2-amino-3-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-propionic acid；2-amino-3-(5-fluoro-2,4-dioxopyrimidin-1-yl)propanoic acid
• CAS: 33233-74-8
• 化学式: C₇H₈FN₃O₄
• 分子量: 217.157
• InChiKey: DBWPFHJYSTVBCZ-UHFFFAOYSA-N

物化性质

• 熔点：
  213-215 °C
• 密度：
  1?+-.0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -4.4
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Pharmacological prophylactics against stress-induced affective disorders and their associated symptoms
  申请人：The Trustees of Columbia University in the City of New York

  公开号：US11110070B2

  公开（公告）日：2021-09-07

  Methods for prophylactically treating a stress-induced affective disorder or stress-induced psychopathology in a subject are provided. Also provided are methods for inducing and/or enhancing stress resilience in a subject. In certain embodiments, an effective amount, of an antagonist of the glutamate N-methyl-D-aspartate (NMDA) receptor, such as ketamine, or a pharmaceutically acceptable salt or derivative thereof, is administered to a subject prior to a stressor.

  本研究提供了预防性治疗应激诱发的情感障碍或应激诱发的精神病理学的方法。还提供了诱导和/或增强受试者应激恢复能力的方法。在某些实施方案中，在应激源之前向受试者施用有效量的谷氨酸N-甲基-D-天冬氨酸（NMDA）受体拮抗剂，如氯胺酮，或其药学上可接受的盐或衍生物。
• Pharmacological prophylactics against stress-induced affective disorders in females
  申请人：The Trustees of Columbia University in the City of New York

  公开号：US11491120B2

  公开（公告）日：2022-11-08

  Methods for prophylactically treating a stress-induced affective disorder or stress-induced psychopathology in a subject are provided. Also provided are methods for inducing and/or enhancing stress resilience in a subject. In certain embodiments, an effective amount of (R,S)-ketamine or (2R, 6R)-hydroxynorketamine ((2R, 6R)-HNK) is administered to a female or male subject prior to a stressor.

  本研究提供了预防性治疗应激诱发的情感障碍或应激诱发的精神病理学的方法。还提供了诱导和/或增强受试者应激恢复能力的方法。在某些实施方案中，在压力源之前，向女性或男性受试者施用有效量的(R,S)-氯胺酮或(2R, 6R)-羟基氯胺酮（(2R, 6R)-HNK）。
• Compositions of a cyclooxygenase-2 selective inhibitior and a non-NMDA glutamate modulator for the treatment of central nervous system damage
  申请人：Stephenson T. Diane

  公开号：US20050101597A1

  公开（公告）日：2005-05-12

  The present invention provides compositions and methods for the treatment of central nervous system damage in a subject. More particularly, the invention provides a combination therapy for the treatment of a central nervous system ischemic condition or a central nervous system traumatic injury comprising the administration to a subject of a non-NMDA glutamate modulator in combination with a cyclooxygenase-2 selective inhibitor.

  本发明提供了治疗受试者中枢神经系统损伤的组合物和方法。更具体地说，本发明提供了一种用于治疗中枢神经系统缺血状况或中枢神经系统创伤性损伤的组合疗法，包括向受试者施用非 NMDA 谷氨酸调节剂与环氧化酶-2 选择性抑制剂的组合疗法。
• GLUTAMATE RECEPTOR ANTAGONISTS AND METHODS OF USE
  申请人：The Johns Hopkins University

  公开号：EP2150248A2

  公开（公告）日：2010-02-10
• PHARMACOLOGICAL PROPHYLACTICS AGAINST STRESS-INDUCED AFFECTIVE DISORDERS AND THEIR ASSOCIATED SYMPTOMS
  申请人：The Trustees of Columbia University in the City of New York

  公开号：EP3377050A1

  公开（公告）日：2018-09-26