{[7-hydroxy-5-(5-methylthiophen-2-yl)[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl]amino}acetic acid hydrochloride | 1262132-34-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: {[7-hydroxy-5-(5-methylthiophen-2-yl)[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl]amino}acetic acid hydrochloride
• CAS: 1262132-34-2
• 化学式: C₁₄H₁₂N₄O₄S*ClH
• 分子量: 368.801
• InChiKey: CRQRYBPQWYMJIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.71
• 重原子数：
  24.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  116.82
• 氢给体数：
  3.0
• 氢受体数：
  7.0

文献信息

• TRIAZOLOPYRIDINE COMPOUND, AND ACTION THEREOF AS PROLYL HYDROXYLASE INHIBITOR OR ERYTHROPOIETIN PRODUCTION-INDUCING AGENT
  申请人：Mitani Ikuo

  公开号：US20130096155A1

  公开（公告）日：2013-04-18

  The present invention provides a triazolopyridine compound having a prolyl hydroxylase inhibitory action and an erythropoietin production-inducing ability. The present invention relates to a compound represented by the following formula [I]: wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, or a solvate thereof, as well as a prolyl hydroxylase inhibitor or erythropoietin production-inducing agent containing the compound. The compound of the present invention shows a prolyl hydroxylase inhibitory action and an erythropoietin production-inducing ability and is useful as a prophylactic or therapeutic agent for various diseases and pathologies (disorders) caused by decreased production of erythropoietin.