tetraethyl (3S,8S,11S,16S,21S)-11-((tert-butoxycarbonyl)amino)-8,16-bis(((S)-1,5-diethoxy-1,5-dioxopentan-2-yl)carbamoyl)-5,10,14,19-tetraoxo-4,9,15,20-tetraazatricosane-1,3,21,23-tetracarboxylate | 866393-01-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tetraethyl (3S,8S,11S,16S,21S)-11-((tert-butoxycarbonyl)amino)-8,16-bis(((S)-1,5-diethoxy-1,5-dioxopentan-2-yl)carbamoyl)-5,10,14,19-tetraoxo-4,9,15,20-tetraazatricosane-1,3,21,23-tetracarboxylate
• CAS: 866393-01-3
• 化学式: C₅₆H₉₁N₇O₂₄
• 分子量: 1246.37
• InChiKey: MYJWVQUXESHANV-OAKHNGAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.75
• 重原子数：
  87.0
• 可旋转键数：
  43.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  423.33
• 氢给体数：
  7.0
• 氢受体数：
  24.0

反应信息

• 作为反应物：
  描述：

  tetraethyl (3S,8S,11S,16S,21S)-11-((tert-butoxycarbonyl)amino)-8,16-bis(((S)-1,5-diethoxy-1,5-dioxopentan-2-yl)carbamoyl)-5,10,14,19-tetraoxo-4,9,15,20-tetraazatricosane-1,3,21,23-tetracarboxylate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 (S)-2-[(S)-2-{(S)-2-Amino-4-[(S)-1,3-bis-((S)-1,3-bis-ethoxycarbonyl-propylcarbamoyl)-propylcarbamoyl]-butyrylamino}-4-((S)-1,3-bis-ethoxycarbonyl-propylcarbamoyl)-butyrylamino]-pentanedioic acid diethyl ester
  参考文献：
  名称：

  Glutamic Acid Dendrimers Attached to a Central Ferrocene Core:  Synthesis and Properties

  摘要：

  The first synthesis of a series of glutamic acid based dendrimers having a central ferrocene core is described. The materials were fully characterized spectroscopically and display strong intramolecular H-bonding. This H-bonding can be disrupted with DMSO. The redox properties of the core are attenuated by the increase in the peptide dendritic sphere. But even at generation 6, there is communication between the exterior and the redox core.

  DOI：

  10.1021/ma050531d
• 作为产物：
  描述：

  Boc-Glu(1)-Glu(OEt)-OEt.N(1)Glu(OEt)-OEt 在 1-羟基苯并三唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 三乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 36.0h， 生成 tetraethyl (3S,8S,11S,16S,21S)-11-((tert-butoxycarbonyl)amino)-8,16-bis(((S)-1,5-diethoxy-1,5-dioxopentan-2-yl)carbamoyl)-5,10,14,19-tetraoxo-4,9,15,20-tetraazatricosane-1,3,21,23-tetracarboxylate
  参考文献：
  名称：

  Glutamic Acid Dendrimers Attached to a Central Ferrocene Core:  Synthesis and Properties

  摘要：

  The first synthesis of a series of glutamic acid based dendrimers having a central ferrocene core is described. The materials were fully characterized spectroscopically and display strong intramolecular H-bonding. This H-bonding can be disrupted with DMSO. The redox properties of the core are attenuated by the increase in the peptide dendritic sphere. But even at generation 6, there is communication between the exterior and the redox core.

  DOI：

  10.1021/ma050531d

文献信息

• WATER-SOLUBLE NANOPARTICLES
  申请人：The Trustees of the University of Pennsylvania

  公开号：US20140004048A1

  公开（公告）日：2014-01-02

  The invention relates to water-soluble nanoparticles and methods for making such nanoparticles. Specifically, the invention relates to dendrimerization to enhance the solubility of nanoparticles.

  本发明涉及水溶性纳米颗粒及其制备方法。具体而言，本发明涉及使用树状分子化学方法来增强纳米颗粒的溶解度。