(2R,3R)-3-[4-(3-formyl-2,5-dimethyl-pyrrol-1-yl)-3-methyl-benzoylamino]-2-hydroxy-4-phenyl-butyric acid | 1415482-99-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: (2R,3R)-3-[4-(3-formyl-2,5-dimethyl-pyrrol-1-yl)-3-methyl-benzoylamino]-2-hydroxy-4-phenyl-butyric acid
• 英文别名: (2R,3R)-3-[[4-(3-formyl-2,5-dimethylpyrrol-1-yl)-3-methylbenzoyl]amino]-2-hydroxy-4-phenylbutanoic acid
• CAS: 1415482-99-3
• 化学式: C₂₅H₂₆N₂O₅
• 分子量: 434.492
• InChiKey: PGWBIKKBWYCYJA-FYYLOGMGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  109
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• NEPRILYSIN INHIBITORS
  申请人：Fleury Melissa

  公开号：US20120308588A1

  公开（公告）日：2012-12-06

  In one aspect, the invention relates to compounds having the formula: where R 1 , R 2 , R 3 , a, R 4 , R 5 , and R 6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

  在一个方面，该发明涉及具有以下结构的化合物：其中R1、R2、R3、a、R4、R5和R6如规范中定义，或其药用可接受盐。这些化合物具有脑利钠酶抑制活性。在另一个方面，该发明涉及包含这些化合物的药物组合物；使用这些化合物的方法；以及制备这些化合物的过程和中间体。
• EP2714648B1
  申请人：——

  公开号：EP2714648B1

  公开（公告）日：2017-08-16
• [EN] NEPRILYSIN INHIBITORS<br/>[FR] INHIBITEURS DE NÉPRILYSINE
  申请人：THERAVANCE INC

  公开号：WO2012166389A1

  公开（公告）日：2012-12-06

  In one aspect, the invention relates to compounds having the formula: (I) where R1, R2, R3, a, R4, R5, and R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.