5-chloro-N-({(5S)-3-[4-(2-imino-1,3-oxazolidin-3-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide hydrochloride | 936232-16-5

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 5-chloro-N-({(5S)-3-[4-(2-imino-1,3-oxazolidin-3-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide hydrochloride
• 英文别名: 5-chloro-N-[[(5S)-3-[4-(2-imino-1,3-oxazolidin-3-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]thiophene-2-carboxamide;hydrochloride
• CAS: 936232-16-5
• 化学式: C₁₈H₁₇ClN₄O₄S*ClH
• 分子量: 457.337
• InChiKey: OYWIZWHYHSWAGY-ZOWNYOTGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.35
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  123
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Phenylene-Bis-Oxazolidine Derivatives and Their Use as Anticoagulants
  申请人：Rohrig Susanne

  公开号：US20100041646A1

  公开（公告）日：2010-02-18

  The present application relates to novel 1,4-phenylene-bis-oxazolidine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular thromboembolic disorders.

  本申请涉及新颖的1,4-苯基-双噁唑啉衍生物，以及它们的制备方法，用于治疗和/或预防疾病的用途，以及用于制备治疗和/或预防疾病的药物，特别是血栓栓塞性疾病。
• PHENYLEN-BIS-OXAZOLIDIN-DERIVATE UND IHRE VERWENDUNG ALS ANTIKOAGULANTIEN
  申请人：Bayer HealthCare AG

  公开号：EP1945634A1

  公开（公告）日：2008-07-23
• [DE] PHENYLEN-BIS-OXAZOLIDIN-DERIVATE UND IHRE VERWENDUNG ALS ANTIKOAGULANTIEN<br/>[EN] PHENYLENEBISOXAZOLIDINE DERIVATIVES AND THEIR USE AS ANTICOAGULANTS<br/>[FR] DERIVES DE PHENYLENE-BIS-OXAZOLIDINE ET LEUR UTILISATION EN TANT QU'ANTICOAGULANT
  申请人：BAYER HEALTHCARE AG

  公开号：WO2007051532A1

  公开（公告）日：2007-05-10

  [EN] The present invention relates to novel 1,4-phenylenebisoxazolidine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
  [FR] La présente invention concerne de nouveaux dérivés de 1,4-phénylène-bis-oxazolidine, des procédés de fabrication de ces dérivés, leur utilisation pour le traitement et/ou la prophylaxie de maladies, ainsi que leur utilisation pour la fabrication de médicaments pour le traitement et/ou la prophylaxie de maladies, notamment de maladies thrombo-emboliques.
  [DE] Die vorliegende Anmeldung betrifft neue 1,4-Phenylen-bis-oxazolidin-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung zur Behandlung und/oder Prophylaxe von Krankheiten sowie ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung und/oder Prophylaxe von Krankheiten, insbesondere von thromboembolischen Erkrankungen.