(S)-2-benzyloxycarbonylamino-4,4-difluoro-heptanoic acid methyl ester | 850646-58-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-2-benzyloxycarbonylamino-4,4-difluoro-heptanoic acid methyl ester
• 英文别名: Methyl (S)-2-benzyloxycarbonylamino-4,4-difluoroheptanoate；(S)-methyl 2-(benzyloxycarbonylamino)-4,4-difluoroheptanoate；methyl (2S)-4,4-difluoro-2-(phenylmethoxycarbonylamino)heptanoate
• CAS: 850646-58-1
• 化学式: C₁₆H₂₁F₂NO₄
• 分子量: 329.344
• InChiKey: UDDHHTOSKAVGSS-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  23
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] DI-FLUORO CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS<br/>[FR] COMPOSÉS CONTENANT UN DI-FLUORO EN TANT QU'INHIBITEURS DE CYSTÉINE PROTÉASE
  申请人：VIROBAY INC

  公开号：WO2009123623A1

  公开（公告）日：2009-10-08

  The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S, and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.

  本发明涉及一种抑制半胱氨酸蛋白酶的化合物，特别是半胱氨酸蛋白酶B、K、L、F和S，因此可用于治疗由这些蛋白酶介导的疾病。本发明涉及包含这些化合物的药物组合物以及其制备方法。
• [EN] NOVEL KETO-OXADIAZOLE DERIVATIVES AS CATHEPSIN INHIBITORS<br/>[FR] NOUVEAUX DERIVES DE CETO-OXADIAZOLE COMME INHIBITEURS DE LA CATHEPSINE
  申请人：AVENTIS PHARMA INC

  公开号：WO2005040142A1

  公开（公告）日：2005-05-06

  Novel difluorinated amide derivatives of Formula (II) as inhibitors of cathepsin S, K, B, and L, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.

  Formula (II)的新颖二氟化酰胺衍生物作为猫hepsin S、K、B和L的抑制剂，其药用盐和N-氧化物，它们作为治疗剂的用途以及其制备方法。
• Novel compounds and compositions as cathepsin inhibitors
  申请人：Thurairatnam Sukanthini

  公开号：US20060189657A1

  公开（公告）日：2006-08-24

  Novel inhibitors of cathepsin S, K, B, and L, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.

  新型卡硫平S、K、B和L的抑制剂，其药学上可接受的盐和N-氧化物，以及它们作为治疗剂的用途和制备方法。
• DI-FLUORO CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS
  申请人：Link John O.

  公开号：US20080293819A1

  公开（公告）日：2008-11-27

  The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S, and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.

  本发明涉及一种抑制半胱氨酸蛋白酶的化合物，特别是抑制蛋白酶B、K、L、F和S，因此对于治疗由这些蛋白酶介导的疾病是有用的。本发明涉及含有这些化合物的制药组合物以及制备它们的方法。
• Spirocyclic nitriles as protease inhibitors
  申请人：SCHUDOK Manfred

  公开号：US20120015933A1

  公开（公告）日：2012-01-19

  The invention relates to substituted carbo- and heterocyclic spiro compounds of the formula Ia which inhibit thiol proteases, to processes for their preparation and to the use thereof as medicaments.

  本发明涉及公式Ia的取代的碳氢杂环螺环化合物，其抑制巯基蛋白酶，以及其制备过程和作为药物的用途。