2,6-bis[2-(oxan-2-yloxy)ethoxymethyl]pyridine | 287183-12-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,6-bis[2-(oxan-2-yloxy)ethoxymethyl]pyridine
• CAS: 287183-12-4
• 化学式: C₂₁H₃₃NO₆
• 分子量: 395.496
• InChiKey: CVTRRIQOCAYYDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  28.0
• 可旋转键数：
  12.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  68.27
• 氢给体数：
  0.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  2,6-bis[2-(oxan-2-yloxy)ethoxymethyl]pyridine 在 对甲苯磺酸 作用下， 以 甲醇 为溶剂， 反应 24.0h， 以81%的产率得到bis<(hydroxy-2 ethoxy)methyl>-2,6 pyridine
  参考文献：
  名称：

  Synthesis and Alkali Metal Picrate Extraction Studies of p-tert-Butylcalix[4]arene Crown Ethers Bridged at the Lower Rim with Pyridyl Units

  摘要：

  The syntheses of pyridyl containing calix[4]arene receptors (4, 5, and 11) that adopt the cone conformation are reported. The complexation properties of these host molecules were estimated via the results of alkali metal picrate extraction experiments. A singly bridged bis-calix[4]arene, i.e. 4 does not appear to be an efficient alkali metal picrate extractant. A doubly-bridged bis-calix[4]arene, i.e. 5, displays elevated extraction avidity toward Rb+ and Cs+ picrates when compared with that of 4. A pyridyl containing calix[4]arene-crown-5, i.e. 11, shows improved avidity and selectivity toward extraction of K+ and Rb+ picrates vis-a-vis the corresponding behavior of 4 and 5. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00160-5
• 作为产物：
  描述：

  2-(2-溴乙氧基)四氢吡喃 、 2,6-吡啶二甲醇 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 72.0h， 以67%的产率得到2,6-bis[2-(oxan-2-yloxy)ethoxymethyl]pyridine
  参考文献：
  名称：

  Synthesis and Alkali Metal Picrate Extraction Studies of p-tert-Butylcalix[4]arene Crown Ethers Bridged at the Lower Rim with Pyridyl Units

  摘要：

  The syntheses of pyridyl containing calix[4]arene receptors (4, 5, and 11) that adopt the cone conformation are reported. The complexation properties of these host molecules were estimated via the results of alkali metal picrate extraction experiments. A singly bridged bis-calix[4]arene, i.e. 4 does not appear to be an efficient alkali metal picrate extractant. A doubly-bridged bis-calix[4]arene, i.e. 5, displays elevated extraction avidity toward Rb+ and Cs+ picrates when compared with that of 4. A pyridyl containing calix[4]arene-crown-5, i.e. 11, shows improved avidity and selectivity toward extraction of K+ and Rb+ picrates vis-a-vis the corresponding behavior of 4 and 5. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00160-5