3-(1-hydroxy-3-oxobut-1-enyl)-6-methoxychromen-2-one | 1192749-45-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 3-(1-hydroxy-3-oxobut-1-enyl)-6-methoxychromen-2-one
• CAS: 1192749-45-3
• 化学式: C₁₄H₁₂O₅
• 分子量: 260.246
• InChiKey: UTRSNSOPUARJHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.29
• 重原子数：
  19.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  76.74
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  2-羟基-5-甲氧基苯甲醛 、 4-羟基-6-甲基-2-吡喃酮 在 EPZ-10 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以93%的产率得到3-(1-hydroxy-3-oxobut-1-enyl)-6-methoxychromen-2-one
  参考文献：
  名称：

  Envirocat EPZ-10: An efficient catalyst for the synthesis of 3-acetoacetylcoumarins

  摘要：

  A simple, efficient and ecofriendly procedure has been developed for the synthesis of 3-acetoacetylcoumarins from salicylaldehyde(s) and 4-hydroxy-6-methyl-2H-pyran-2-one using EPZ-10 as a catalyst in ethanol medium at reflux condition. The present methodology offers several advantages such as excellent yields, short reaction time and use of EPZ-10 as an eco-friendly catalyst. (C) 2011 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.crci.2011.08.002

文献信息

• Envirocat EPZ-10: An efficient catalyst for the synthesis of 3-acetoacetylcoumarins
  作者：T.S. Shaikh、K.A. Undale、D.S. Gaikwad、D.M. Pore

  DOI：10.1016/j.crci.2011.08.002

  日期：2011.11

  A simple, efficient and ecofriendly procedure has been developed for the synthesis of 3-acetoacetylcoumarins from salicylaldehyde(s) and 4-hydroxy-6-methyl-2H-pyran-2-one using EPZ-10 as a catalyst in ethanol medium at reflux condition. The present methodology offers several advantages such as excellent yields, short reaction time and use of EPZ-10 as an eco-friendly catalyst. (C) 2011 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.