1-(2-chloro-phenyl)-3-(2-{4-[(S)-2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-1H-benzoimidazol-4-yl)-urea | 1095322-06-7

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 1-(2-chloro-phenyl)-3-(2-{4-[(S)-2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-1H-benzoimidazol-4-yl)-urea
• 英文别名: 1-(2-chlorophenyl)-3-[2-[4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-2-oxo-1H-pyridin-3-yl]-1H-benzimidazol-4-yl]urea
• CAS: 1095322-06-7
• 化学式: C₂₇H₂₂Cl₂N₆O₃
• 分子量: 549.416
• InChiKey: NKSPUAXKBCYOLK-JOCHJYFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  38
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  131
• 氢给体数：
  6
• 氢受体数：
  5

文献信息

• BENZIMIDAZOLE AMIDO DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS
  申请人：Georges Guy

  公开号：US20100168181A1

  公开（公告）日：2010-07-01

  Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

  本发明的对象是公式(I)的化合物及其药学上可接受的盐、对映体、非对映异构体和外消旋体，上述化合物的制备、含有它们的药物及其制造，以及上述化合物在控制或预防癌症等疾病中的应用。
• BENZIMIDAZOLE AMIDO DERIVATIVES AS KINASE INHIBITORS
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2170859A1

  公开（公告）日：2010-04-07
• US7956190B2
  申请人：——

  公开号：US7956190B2

  公开（公告）日：2011-06-07
• [EN] BENZIMIDAZOLE AMIDO DERIVATIVES AS KINASE INHIBITORS<br/>[FR] DÉRIVÉS AMIDO DU BENZIMIDAZOLE EN TANT QU'INHIBITEURS DE KINASE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2009000489A1

  公开（公告）日：2008-12-31

  [EN] Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
  [FR] La présente invention porte sur les composés de formule (I), sur leurs sels acceptables du point de vue pharmaceutique, leurs formes énantiomériques, leurs diastéréoisomères et leurs racémates, sur la préparation des composés mentionnés ci-dessus, sur des médicaments les contenant et sur leur fabrication, ainsi que sur l'utilisation des composés mentionnés ci-dessus dans le contrôle ou la prévention des maladies telles que le cancer.