甲基(1R)-3-(苯甲酰氧基)-8-羟基-8-氮杂二环[3.2.1]辛烷-2-羧酸酯 | 123924-38-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 甲基(1R)-3-(苯甲酰氧基)-8-羟基-8-氮杂二环[3.2.1]辛烷-2-羧酸酯
• 英文名称: Seryl-glutamyl-lysyl-aspartyl-glutamyl-leucine
• 英文别名: (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-4-carboxybutanoyl]amino]hexanoyl]amino]-3-carboxypropanoyl]amino]-4-carboxybutanoyl]amino]-4-methylpentanoic acid
• CAS: 123924-38-9
• 化学式: C₂₉H₄₉N₇O₁₄
• 分子量: 719.7
• InChiKey: BKWMKTIGFLPGOV-RABCQHRBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -8.4
• 重原子数：
  50
• 可旋转键数：
  26
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  367
• 氢给体数：
  12
• 氢受体数：
  16

文献信息

• Production of highly thermally stable recombinant cholinesterases for the detection, detoxification and decontamination of organophosphorus compounds
  申请人：Rosenberg Yvonne

  公开号：US10221402B2

  公开（公告）日：2019-03-05

  Disclosed herein are methods for the large-scale production of a highly thermally stable acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Additionally, the expression methods disclosed herein can produce ChE preparations consisting of extract or purified forms that can be produced in high amounts and are highly thermally stable. These ChE products can be used in vitro detection, detoxification and decontamination methods.

  本文公开了大规模生产高热稳定性乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶（BChE）的方法。此外，本文公开的表达方法还可以生产由提取物或纯化形式组成的 ChE 制剂，这些制剂可以大量生产并且具有高度热稳定性。这些 ChE 产品可用于体外检测、解毒和净化方法。
• PRODUCTION OF HIGHLY THERMALLY STABLE RECOMBINANT CHOLINESTERASES FOR THE DETECTION, DETOXIFICATION AND DECONTAMINATION OF ORGANOPHOSPHORUS COMPOUNDS
  申请人：Rosenberg Yvonne

  公开号：US20170081649A1

  公开（公告）日：2017-03-23

  Disclosed herein are methods for the large-scale production of a highly thermally stable acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Additionally, the expression methods disclosed herein can produce ChE preparations consisting of extract or purified forms that can be produced in high amounts and are highly thermally stable. These ChE products can be used in vitro detection, detoxification and decontamination methods.
• [EN] PRODUCTION OF HIGHLY THERMALLY STABLE RECOMBINANT CHOLINESTERASES FOR THE DETECTION, DETOXIFICATION AND DECONTAMINATION OF ORGANOPHOSPHORUS COMPOUNDS<br/>[FR] PRODUCTION DE CHOLINESTÉRASES RECOMBINANTES À GRANDE STABILITÉ THERMIQUE POUR LA DÉTECTION, LA DÉTOXICATION ET LA DÉCONTAMINATION DE COMPOSÉS ORGANOPHOSPHORÉS
  申请人：ROSENBERG YVONNE

  公开号：WO2015142679A1

  公开（公告）日：2015-09-24

  Disclosed herein are methods for the large-scale production of a highly thermally stable acetylcholinesterase (AChE) and butyrylcholmesterase (BChE). Additionally, the expression methods disclosed herein can produce ChE preparations consisting of extract or purified forms that can be produced in high amounts and are highly thermally stable. These ChE products can be used in vitro detection, detoxification and decontamination methods.