N,N'-(dimethacryloyloxy)glutarylamide | 615559-44-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N'-(dimethacryloyloxy)glutarylamide
• 英文别名: [[5-(2-Methylprop-2-enoyloxyamino)-5-oxopentanoyl]amino] 2-methylprop-2-enoate
• CAS: 615559-44-9
• 化学式: C₁₃H₁₈N₂O₆
• 分子量: 298.296
• InChiKey: FHTMKJKSFRBHLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  21
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  111
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• DEGRADABLE CROSSLINKERS, AND DEGRADABLE CROSSLINKED HYDROGELS COMPRISING THEM
  申请人：——

  公开号：US20030199654A1

  公开（公告）日：2003-10-23

  One aspect of the present invention relates to base-labile crosslinkers. A second aspect of the present invention relates to degradable crosslinked polymers and hydrogels comprising a base-labile crosslinker. The present invention also relates to a method of influencing the degradation rate of a crosslinked polymer or hydrogel, comprising the step of incorporating uncharged acrylamides into the crosslinked polymer or hydrogel.

  本发明的一个方面涉及嗜碱交联剂。本发明的第二个方面涉及包含碱亲和性交联剂的可降解交联聚合物和水凝胶。本发明还涉及一种影响交联聚合物或水凝胶降解率的方法，包括将不带电的丙烯酰胺掺入交联聚合物或水凝胶的步骤。
• Embolization using degradable crosslinked hydrogels
  申请人：——

  公开号：US20030215519A1

  公开（公告）日：2003-11-20

  One aspect of the present invention relates to a method of temporarily embolizing a blood vessel using a hydrolytically degradable crosslinked hydrogel as an embolus. In certain embodiments, the hydrolytically degradable crosslinked hydrogel substantially hydrolyzes only at about physiological pH. In certain embodiments of the method, the hydrolytically degradable crosslinked hydrogel is stable at low pH. In certain embodiments of the method, the hydrolytically degradable crosslinked hydrogel comprises a marker molecule, such as a dye, radiopaque, or an MRI-visible compound. It is to be understood that both the foregoing general description and the following detailed description are exemplary, and are intended to provide further explanation of the invention as claimed.

  本发明的一个方面涉及一种使用可水解降解交联水凝胶作为栓子临时栓塞血管的方法。在某些实施方案中，可水解降解交联水凝胶基本上只在生理 pH 值左右水解。在该方法的某些实施方案中，可水解降解交联水凝胶在低 pH 值下是稳定的。在该方法的某些实施方案中，可水解降解交联水凝胶包含标记分子，如染料、不透射线或核磁共振成像可视化合物。应当理解的是，前面的一般性描述和下面的详细描述都是示例性的，旨在对所要求的本发明提供进一步的解释。
• Degradable crosslinkers, and degradable crosslinked hydrogels comprising them
  申请人：Zhang Hongmin

  公开号：US20050113285A1

  公开（公告）日：2005-05-26

  One aspect of the present invention relates to base-labile crosslinkers. A second aspect of the present invention relates to degradable crosslinked polymers and hydrogels comprising a base-labile crosslinker. The present invention also relates to a method of influencing the degradation rate of a crosslinked polymer or hydrogel, comprising the step of incorporating uncharged acrylamides into the crosslinked polymer or hydrogel.

  本发明的一个方面涉及嗜碱交联剂。本发明的第二个方面涉及包含碱亲和性交联剂的可降解交联聚合物和水凝胶。本发明还涉及一种影响交联聚合物或水凝胶降解率的方法，包括将不带电的丙烯酰胺掺入交联聚合物或水凝胶的步骤。
• US6713646B2
  申请人：——

  公开号：US6713646B2

  公开（公告）日：2004-03-30
• US7135593B2
  申请人：——

  公开号：US7135593B2

  公开（公告）日：2006-11-14