2-Allyl-oenanthamid | 100049-57-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-Allyl-oenanthamid
• 英文别名: 2-Hexyl-4-pentenamide；2-prop-2-enyloctanamide
• CAS: 100049-57-8
• 化学式: C₁₁H₂₁NO
• 分子量: 183.294
• InChiKey: PHZZMBWUXMSSII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  5-Allyl-5-hexyl-2-thioxo-dihydro-pyrimidine-4,6-dione 在 氨 作用下， 生成 2-Allyl-oenanthamid
  参考文献：
  名称：

  Hydrolysis of 5,5-Disubstituted Barbituric Acids

  摘要：

  DOI：

  10.1021/jo01060a048

文献信息

• [EN] MACROCYCLIC SH2 DOMAIN BINDING INHIBITORS<br/>[FR] INHIBITEURS DE LIAISON DE DOMAINE SH2 MACROCYCLIQUE
  申请人：US GOV HEALTH & HUMAN SERV

  公开号：WO2006039527A1

  公开（公告）日：2006-04-13

  Disclosed are compounds for inhibiting the binding of an SH2 domain-containing protein, for example, a compound of formula (I): FORMULA (I) wherein R1 is a lipophile; R2, in combination with the phenyl ring, is a phenylphosphate mimic group or a protected phenylphosphate mimic group; R3 is, for example, hydrogen, azido, amino, oxalylamino, carboxy alkyl, alkoxycarbonyl alkyl, aminocarbonyl alkyl, or alkyl carbonylamino; R6 is a linker; AA is an amino acid; and n is 1 to 6; or a pharmaceutically acceptable salt, stereoisomer, solvate, or hydrate thereof. Also disclosed are pharmaceutical compositions and methods of use of such compounds.

  本文披露了用于抑制含有SH2结构域蛋白质结合的化合物，例如，具有以下结构的化合物（I）：FORMULA（I）其中R1是脂溶性基团；R2与苯环结合形成苯磷酸酯模拟基团或受保护的苯磷酸酯模拟基团；R3是，例如，氢、偶氮基、氨基、草酰氨基、羧基烷基、烷氧羰基烷基、氨基羰基烷基或烷基羰基氨基；R6是连接基；AA是氨基酸；n为1至6；或其药学上可接受的盐、立体异构体、溶剂合物或水合物。还披露了包括这些化合物的药物组合物和使用方法。
• MACROCYCLIC SH2 DOMAIN BINDING INHIBITORS
  申请人：Government of the United States of America, Represented by the Secretary, Department of Health and Human Services

  公开号：EP1793843A1

  公开（公告）日：2007-06-13
• BIOCIDAL AZOLE EMULSION CONCENTRATES HAVING HIGH ACTIVE INGREDIENT CONTENT
  申请人：Phibro-Tech Inc.

  公开号：EP2043446A2

  公开（公告）日：2009-04-08
• Macrocyclic Sh2 Domain Binding Inhibitors
  申请人：Burke Terrence R.

  公开号：US20080139456A1

  公开（公告）日：2008-06-12

  Disclosed are compounds for inhibiting the binding of an SH2 domain-containing protein, for example, a compound of formula (I): FORMULA (I) wherein R1 is a lipophile; R2, in combination with the phenyl ring, is a phenylphosphate mimic group or a protected phenylphosphate mimic group; R3 is, for example, hydrogen, azido, amino, oxalylamino, carboxy alkyl, alkoxycarbonyl alkyl, aminocarbonyl alkyl, or alkyl carbonylamino; R6 is a linker; AA is an amino acid; and n is 1 to 6; or a pharmaceutically acceptable salt, stereoisomer, solvate, or hydrate thereof. Also disclosed are pharmaceutical compositions and methods of use of such compounds.
• [EN] BIOCIDAL AZOLE EMULSION CONCENTRATES HAVING HIGH ACTIVE INGREDIENT CONTENT<br/>[FR] CONCENTRES D'EMULSION D'AZOLE BIOCIDE AYANT UNE TENEUR ELEVEE EN SUBSTANCE ACTIVE
  申请人：PHIBRO TECH INC

  公开号：WO2007092580A2

  公开（公告）日：2007-08-16

  [EN] A concentrated stable emulsifiable formulation includes A) an amide, B) a water-soluble non-ionic emulsifier, C) a water-insoluble anionic emulsifier, and D) a water-insoluble biocidal azole, wherein the concentrated stable emulsifiable formulation is a solution containing the water-insoluble biocidal azole in an amount greater than 20% by weight of the formulation. An aqueous wood treatment composition which can be made for example from the concentrated stable emulsifiable formulation includes emulsified droplets containing at least one water-insoluble biocidal azole s and an amide such as N,N- dialkyloctanamide, N,N-dialkyldecanamide, N-alkyloctanamide, N-alkyldecanamide, octanamide, decanamide, or mixture thereof, where the alkyl groups independently comprise between one and three carbon atoms.
  [FR] La présente invention concerne une formulation émulsifiable stable concentrée comprenant A) un amide, B) un émulsifiant non ionique hydrosoluble, C) un émulsifiant anionique insoluble dans l'eau et D) un azole biocide insoluble dans l'eau, la formulation émulsifiable stable concentrée étant une solution contenant l'azole biocide insoluble dans l'eau en une quantité supérieure à 20 % en poids de la formulation. Une composition aqueuse de traitement du bois qui peut être préparée, par exemple, à partir de la formulation émulsifiable stable concentrée, comprend des gouttelettes émulsifiées contenant au moins un azole biocide insoluble dans l'eau et un amide tel qu'un N,N-dialkyloctanamide, un N,N-dialkyldécanamide, un N-alkyloctanamide, un N-alkyldécanamide, l'octanamide, le décanamide ou un mélange de ceux-ci, les groupes alkyle contenant indépendamment entre un et trois atomes de carbone.