4-[1,2-bis(diphenylphosphoryl)ethyl]-N,N-dimethylaniline | 65164-87-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[1,2-bis(diphenylphosphoryl)ethyl]-N,N-dimethylaniline
• CAS: 65164-87-6
• 化学式: C₃₄H₃₃NO₂P₂
• 分子量: 549.589
• InChiKey: RPIOHPNTVZLVAK-UHFFFAOYSA-N

物化性质

• 沸点：
  676.8±55.0 °C(Predicted)
• 密度：
  1.22±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-[1,2-bis(diphenylphosphoryl)ethyl]-N,N-dimethylaniline 在 titanium(IV) isopropylate 、 三乙氧基硅烷 作用下， 以 苯 为溶剂， 反应 0.42h， 以98%的产率得到1-(4'-N,N-dimethylaminophenyl)-1,2-bis(diphenylphosphino)ethane
  参考文献：
  名称：

  Facile synthesis of chelating bisphosphine oxides and bisphosphines via palladium-catalyzed bishydrophosphinylation reactions

  摘要：

  A series of functional bisphosphosphine oxides were synthesized in good yields via new Pd-catalyzed bis-hydrophosphinylation reactions of terminal alkynes and diphenylphosphine oxide. The resulting bisphosphine oxides were reduced to their corresponding bisphosphines in quantitative yields via a Ti((OPr)-Pr-i)(4)-mediated process. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00609-3
• 作为产物：
  描述：

  4-二甲基氨基苯乙炔 、 Diphenylphosphine oxide 在 四(三苯基膦)钯 作用下， 以 甲苯 为溶剂， 反应 20.0h， 以71%的产率得到4-[1,2-bis(diphenylphosphoryl)ethyl]-N,N-dimethylaniline
  参考文献：
  名称：

  Facile synthesis of chelating bisphosphine oxides and bisphosphines via palladium-catalyzed bishydrophosphinylation reactions

  摘要：

  A series of functional bisphosphosphine oxides were synthesized in good yields via new Pd-catalyzed bis-hydrophosphinylation reactions of terminal alkynes and diphenylphosphine oxide. The resulting bisphosphine oxides were reduced to their corresponding bisphosphines in quantitative yields via a Ti((OPr)-Pr-i)(4)-mediated process. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00609-3