1-Acetylazetidine-3-carbonitrile | 2112395-13-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-Acetylazetidine-3-carbonitrile
• CAS: 2112395-13-6
• 化学式: C₆H₈N₂O
• 分子量: 124.14
• InChiKey: AAQZFAVTUWYUOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• 2-Thioethenyl substituted carbapenem derivatives
  申请人：Maruyama Takahisa

  公开号：US20070004700A1

  公开（公告）日：2007-01-04

  [Objective] An objective of the present invention is to provide compounds that are effective against various resistant bacteria which cause current clinical problems, for example, pneumococci including penicillin resistant Streptococcus pneumoneae (PRSP), Haemophilus influenzae including bata-lactamase-nonproducing ampicillin-resistant Haemophilus influenzae (BLNAR), and Moraxella ( Branhamella ) catarrhalis. [Structure] The present invention provides 2-ethenylthio-based carbapenem derivatives represented by the formula (I) or pharmaceutically acceptable salts thereof that are effective, for example, against pneumococci including penicillin resistant Streptococcus pneumoneae (PRSP), Haemophilus influenzae including beta-lactamase-nonproducing ampicillin-resistant Haemophilus influenzae (BLNAR), and Moraxella (Branhamella) catarrhalis:

  本发明的一个目标是提供对抗引起当前临床问题的各种耐药细菌有效的化合物，例如对抗青霉素耐药的肺炎球菌（PRSP）、包括产β-内酰胺酶非产生性氨苄青霉素耐药的流感嗜血杆菌（BLNAR）和喜马拉雅链球菌（布兰氏链球菌）等。本发明提供了以公式（I）表示的基于2-乙烯硫的碳青霉烯衍生物或其药用可接受盐，例如对抗青霉素耐药的肺炎球菌（PRSP）、包括产β-内酰胺酶非产生性氨苄青霉素耐药的流感嗜血杆菌（BLNAR）和喜马拉雅链球菌（布兰氏链球菌）有效。
• [EN] FLUORINATED LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS FLUORÉS DE LA LYSYL OXYDASE-LIKE 2 ET UTILISATIONS DESDITS INHIBITEURS
  申请人：PHARMAKEA INC

  公开号：WO2016144703A1

  公开（公告）日：2016-09-15

  Described herein are compounds that are LOXL2 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with LOXL2 activity.

  本文描述的是一种LOXL2抑制剂化合物，制备这种化合物的方法，包含这种化合物的药物组合物和药物，以及使用这种化合物治疗与LOXL2活性相关的疾病、病症或疾病的方法。
• [EN] MLL1 INHIBITORS AND ANTI-CANCER AGENTS<br/>[FR] INHIBITEURS DE MLL1 ET AGENTS ANTICANCÉREUX
  申请人：NOVARTIS AG

  公开号：WO2021053617A1

  公开（公告）日：2021-03-25

  The present invention provides a compound of Formula (I): or an enantiomer, an enantiomeric mixture, or a pharmaceutically acceptable salt thereof; wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds; and methods of using such compounds for treating a disease or condition mediated by mixed lineage leukemia 1 (MLL).

  本发明提供了化合物的结构式(I)：或其对映体、对映体混合物或其药用可接受的盐；其中变量如本文所定义。本发明还提供了包含这些化合物的药物组合物；以及利用这些化合物治疗由混合系谱白血病1（MLL）介导的疾病或症状的方法。
• [EN] PYRIDAZINE DERIVATIVES AS RORc MODULATORS<br/>[FR] DÉRIVÉS DE PYRIDAZINE EN TANT QUE MODULATEURS DE RORC
  申请人：HOFFMANN LA ROCHE

  公开号：WO2016177686A1

  公开（公告）日：2016-11-10

  Compounds of formula (I): or pharmaceutical salts thereof, wherein m, n, A, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

  公式（I）的化合物：或其药用盐，其中m、n、A、R1、R2、R3、R4和R5的定义如本文所述。还公开了制备这些化合物的方法，并将这些化合物用于治疗炎症性疾病，如关节炎。
• 2- thioethenyl substituted carbapenem derivatives
  申请人：Maruyama Takahisa

  公开号：US20100145063A1

  公开（公告）日：2010-06-10

  2-Ethenylthio-type carbapenem derivatives of formula (I) or pharmaceutically acceptable salts thereof are provided. The compounds according to the present invention have potent antimicrobial activity and a wide antimicrobial spectrum against pneumococci including penicillin resistant Streptococcus pneumoniae (PRSP), Haemophilus influenzae including β-lactamase-negative, ampicillin-resistant Haemophilus influenzae (BLNAR), and Moraxella ( Branhamella ) catarrhalis .

  本发明提供了式(I)或其药学上可接受的盐的2-乙烯基硫代类碳青霉烯衍生物。根据本发明，这些化合物具有强效的抗微生物活性，并且对包括青霉素耐药的肺炎链球菌（PRSP）、包括β-内酰胺酶阴性、氨苄青霉素耐药的流感嗜血杆菌（BLNAR）和猪杆菌（布兰氏杆菌）在内的多种肺炎球菌具有广谱抗微生物活性。