(2R,3S)-2,3-dihydroxy-2-isobutylsuccinic acid | 60192-20-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2R,3S)-2,3-dihydroxy-2-isobutylsuccinic acid
• 英文别名: (2R,3S)-2,3-dihydroxy-2-(2-methylpropyl)butanedioic acid；(+)-(2R,3S)-2-isobutyltartric acid；(2R,3S)-2-Isobutylweinsaeure
• CAS: 60192-20-3
• 化学式: C₈H₁₄O₆
• 分子量: 206.196
• InChiKey: AVXYKBZOBCDCCU-SVGQVSJJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.71
• 重原子数：
  14.0
• 可旋转键数：
  5.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  115.06
• 氢给体数：
  4.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  Dimethyl-(+/-)-erythro-isobutyltartrat 在 盐酸 作用下， 生成 (2R,3S)-2,3-dihydroxy-2-isobutylsuccinic acid
  参考文献：
  名称：

  Behr,D. et al., Acta chemica Scandinavica. Series B. Organic chemistry and biochemistry, 1976, vol. 30, p. 309 - 312

  摘要：

  DOI：

文献信息

• Bis(4-glycosyloxybenzyl) 2-isobutyltartrate and dihydrophenanthrene derivatives from the pseudobulbs of Pholidota chinensis and their anti-inflammatory activity
  作者：Cheng-Ming Tsai、Chun-Yu Chen、Phung Kim Le、Yi-Hsuan Wang、Sio-Hong Lam

  DOI：10.1016/j.phytochem.2022.113528

  日期：2023.2

  Six previously undescribed components, bis(4-glycosyloxybenzyl) 2-isobutyltartrate derivatives (pholidotoside A-E) and phenolic glycoside (pholidotosin A), together with twenty known compounds were isolated from the pseudobulbs of Pholidota chinensis. Their structures and absolute configuration were elucidated and established through various spectroscopic and chemical methods. The anti-inflammatory

  从Pholidota chinensis的假鳞茎中分离出六种以前未描述的成分，双（4-糖基氧基苄基）2-异丁基酒石酸酯衍生物（pholidotoside AE）和酚糖苷（pholidotosin A）以及二十种已知化合物。通过各种光谱和化学方法阐明和确定了它们的结构和绝对构型。使用由N-甲酰-甲硫氨酰-亮氨酰-苯丙氨酸/细胞松弛素 B (fMLP/CB)激活的人中性粒细胞模型检查所选化合物的抗炎潜力。其中，二氢菲对超氧阴离子生成和弹性蛋白酶释放测定均表现出有效的抑制作用，IC 50值范围为 0.41 ± 0.05 至 7.14 ± 0.30 μM。
• Glycosidic Constituents of the Tubers of <i>Gymnadenia conopsea</i>
  作者：Jiachen Zi、Shuai Li、Mingtao Liu、Maoluo Gan、Sheng Lin、Weixia Song、Yanling Zhang、Xiaona Fan、Yongchun Yang、Jianjun Zhang、Jiangong Shi、Duolong Di

  DOI：10.1021/np070670j

  日期：2008.5.1

  Ten minor new glycosidic constituents (1-10), together with 10 known compounds, have been isolated from a neuroprotective fraction of an ethanolic extract of the tubers of Gymnadenia conopsea. The structures of 1-10 were determined using spectroscopic and chemical methods. The compounds isolated were evaluated for activity in in vitro assays for acetylcholine esterase and monoamine oxidase inhibitory activities.