quinuclidine-dicyanohydroborane | 197140-56-0

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: quinuclidine-dicyanohydroborane
• 英文别名: 1-Azoniabicyclo[2.2.2]octan-1-yl(dicyano)boranuide
• CAS: 197140-56-0
• 化学式: C₉H₁₄BN₃
• 分子量: 175.041
• InChiKey: WTJFGLLEHAJOIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.47
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  47.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  quinuclidine-dicyanohydroborane 、 triethyloxonium fluoroborate 以 二氯甲烷 为溶剂， 以88%的产率得到quinuclidine-bis(ethylnitrilium)hydroboron(2+) tetrafluoroborate
  参考文献：
  名称：

  Synthesis of the first amine–dicarboxyboranes and their derivatives

  摘要：

  通过[胺双(乙基硝基)氢硼(2+)]四氟硼酸盐、[胺双(C-羟基-N-乙基亚氨基)氢硼(2 )]阳离子和胺双(N-乙基氨基甲酰基)硼烷，从胺双氰基硼烷合成了第一种胺双硼烷及其二甲酯；与硼相邻的 C-甲氧基-N-乙基亚氨基基团发生了不寻常的水解。

  DOI：

  10.1039/a702843a
• 作为产物：
  描述：

  奎宁环 、 4-cyanopyridine-dicyanohydroborane 以 乙腈 为溶剂， 以96%的产率得到quinuclidine-dicyanohydroborane
  参考文献：
  名称：

  Synthesis of the first amine–dicarboxyboranes and their derivatives

  摘要：

  通过[胺双(乙基硝基)氢硼(2+)]四氟硼酸盐、[胺双(C-羟基-N-乙基亚氨基)氢硼(2 )]阳离子和胺双(N-乙基氨基甲酰基)硼烷，从胺双氰基硼烷合成了第一种胺双硼烷及其二甲酯；与硼相邻的 C-甲氧基-N-乙基亚氨基基团发生了不寻常的水解。

  DOI：

  10.1039/a702843a

文献信息

• Synthesis of Amine-dicyanohydroboranes, [Amine-bis(ethylnitrilium)hydroboron(2+)] Tetrafluoroborates, and Their Derivatives as Precursors of Amine-dicarboxyboranes
  作者：Zoltán Berente、Béla Györi

  DOI：10.1021/ic990023i

  日期：1999.11.1

  Numerous amine-dicyanohydroboranes [A.BH(CN)(2), 1, A = quinuclidine (Q, c), trimethylamine (Me3N, d), 4-picoline (Pic, e), 4-(dimethylamino)pyridine (DMAP, f), N,N,N',N'-tetramethylethylenediamine (TMEDA, j), 1.4-diazabicyclo[2.2.2]octane (DABCO, k)] have been prepared by base exchange reactions from 4-cyanopyridine-dicyanohydroborane (4-CN-py.BH(CN)(2), 1a). In analogous experiments with secondary amines [piperidine (g), diethylamine (h), and morpholine (i)] 1a underwent aminodecyanation also, probably via SNAr mechanism, which demonstrates the strong electron-withdrawing effect of the >N.BHX2 moiety toward the substituents on the nitrogen. Amine-dicyanohydroboranes have been transformed into [amine-bis(C-hydroxy-N-ethylimidate)hydroboron(2+)] (3) [amine-N-ethylcarbamoyl(C-hydroxy-N-ethylimido)hydroboron(1+)] (4), [amine-bis(C-methoxy-N-ethylimidate)hydroboron(2+)] (5), [amine-bis(amidinium)hydroboron(2+)] (6), and [amine-bis(triethylamidinium)hydroboron(2+)] (7) cations, precursors of amine-dicarboxyboranes and their derivatives. These transformations were carried out in two steps. First, the otherwise nonreactive cyano groups were activated by ethylation employing Et3OBF4, yielding [amine-bis(ethylnitrilium)hydroboron(2+)] tetrafluoroborates (2), then 3-7 were obtained by nucleophilic addition to 2. The pK(a) values corresponding to the protonation of the N-ethylamide group were found to be extremely high (3.1-3.3), which demonstrates the strong electron-donating effect of >N.BHX2 moiety toward the substituents on the boron.