Simple and Stereoselective Syntheses of Nucleoside Analogues with a Benzo[c]furan Glycone Moiety
作者:David F. Ewing、Noureddine Fahmi、Grahame Mackenzie、Alessandra Pranzo
DOI:10.1080/15257779908041494
日期:1999.4
A series of d4T analogues have been synthesised in which the 2',3'didehydro-2',3'-dideoxyribose moiety is replaced by a benzo[c]furan core. A simple strategy has been developed to access a range of compounds for biological screening. In addition, a stereoselective approach has been achieved with view to permit more detailed studies.