ethyl 4-carbamoyl-2,4,5,6-tetrahydro-1,3,4,6,6-pentamethylcyclopenta[c]pyrrole-2-acetate | 54610-10-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl 4-carbamoyl-2,4,5,6-tetrahydro-1,3,4,6,6-pentamethylcyclopenta[c]pyrrole-2-acetate
• 英文别名: ethyl 2-(4-carbamoyl-1,3,4,6,6-pentamethyl-5H-cyclopenta[c]pyrrol-2-yl)acetate
• CAS: 54610-10-5
• 化学式: C₁₇H₂₆N₂O₃
• 分子量: 306.405
• InChiKey: FUYGPVSERBOVMN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.09
• 重原子数：
  22.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  74.32
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  ethyl 4-carbamoyl-2,4,5,6-tetrahydro-1,3,4,6,6-pentamethylcyclopenta[c]pyrrole-2-acetate 、 sodium hydroxide 以affords 4-carbamoyl-2,4,5,6-tetrahydro-1,3,4,6,6-pentamethylcyclopenta[c]pyrrole-2-acetic acid的产率得到4-Carbamoyl-2,4,5,6-tetrahydro-1,3,4,6,6-pentamethylcyclopenta[c]pyrrole-2-acetic acid
  参考文献：
  名称：

  Cyclopenta[c]pyrrole derivatives

  摘要：

  2,4,5,6-四氢环戊[c]吡咯-4-羧酰胺和4-硫代羧酰胺衍生物可用作抗分泌和抗溃疡剂，通过对应的2,4,5,6-四氢环戊[c]吡咯-4-碳腈的水解或硫代水解制备，或在硫代羧酰胺的情况下，通过4-羧酰胺与五硫化二磷反应制备。

  公开号：

  US04098797A1

文献信息

• Cyclopenta[o]pyrrole derivatives
  申请人：Sterling Drug Inc.

  公开号：US04220763A1

  公开（公告）日：1980-09-02

  2,4,5,6-Tetrahydrocyclopenta[c]pyrrole-4-carboxamide and 4-thiocarboxamide derivatives useful as antisecretory and anti-ulcer agents are prepared by hydrolysis or thiohydrolysis of the corresponding 2,4,5,6-tetrahydrocyclopenta[c]pyrrole-4-carbonitriles or, in the case of the thiocarboxamides, by reaction of the 4-carboxamide with phosphorus pentasulfide.

  2,4,5,6-四氢环戊[c]吡咯-4-羧酰胺和4-硫代羧酰胺衍生物是作为抗分泌和抗溃疡剂有用的，通过对应的2,4,5,6-四氢环戊[c]吡咯-4-碳腈的水解或硫酸盐水解制备，或在硫代羧酰胺的情况下，通过4-羧酰胺与五硫化二磷反应制备。
• Phenyl and lower alkyl substituted pyrrole-3-acrylonitriles
  申请人：Sterling Drug Inc.

  公开号：US04273713A1

  公开（公告）日：1981-06-16

  2,4,5,6-Tetrahydrocyclopenta[c]pyrrole-4-carboxamide and 4-thiocarboxamide derivatives useful as anti-secretory and anti-ulcer agents are prepared by hydrolysis of thiohydrolysis of the corresponding 2,4,5,6-tetrahydrocyclopenta[c]pyrrole-4-carbonitriles or, in the case of the thiocarboxamides, by reaction of the 4-carboxamide with phosphorus pentasulfide.

  2,4,5,6-四氢环戊[c]吡咯-4-羧酰胺和4-硫代羧酰胺衍生物可用作抗分泌和抗溃疡剂，通过对应的2,4,5,6-四氢环戊[c]吡咯-4-碳腈的硫水解或水解，或在硫代羧酰胺的情况下，通过4-羧酰胺与五硫化二磷的反应制备。
• Cyclopenta (C) pyrrole derivatives
  申请人：Sterling Drug Inc.

  公开号：US04126620A1

  公开（公告）日：1978-11-21

  2,4,5,6-Tetrahydrocyclopenta[c]pyrrole-4-carboxamide and 4-thiocarboxamide derivatives useful as antisecretory and anti-ulcer agents are prepared by hydrolysis or thiohydrolysis of the corresponding 2,4,5,6-tetrahydrocyclopenta[c]pyrrole-4-carbonitriles or, in the case of the thiocarboxamides, by reaction of the 4-carboxamide with phosphorus pentasulfide.

  2,4,5,6-四氢环戊[c]吡咯-4-羧酰胺和4-硫代羧酰胺衍生物被用作抗分泌和抗溃疡剂，通过对应的2,4,5,6-四氢环戊[c]吡咯-4-碳腈的水解或硫代水解制备，或在硫代羧酰胺的情况下，通过4-羧酰胺与五硫化二磷反应制备。
• Cyanocyclopenta[c]pyrrole derivatives
  申请人：Sterling Drug Inc.

  公开号：US04140854A1

  公开（公告）日：1979-02-20

  2,4,5,6-Tetrahydrocyclopenta[c]pyrrole-4-carboxamide and 4-thiocarboxamide derivatives useful as antisecretory and anti-ulcer agents are prepared by hydrolysis or thiohydrolysis of the corresponding 2,4,5,6-tetrahydrocyclopenta[c]pyrrole-4-carbonitriles or, in the case of the thiocarboxamides, by reaction of the 4-carboxamide with phosphorus pentasulfide.

  2,4,5,6-四氢环戊[c]吡咯-4-羧酰胺和4-硫代羧酰胺衍生物可作为抗分泌和抗溃疡剂，通过对应的2,4,5,6-四氢环戊[c]吡咯-4-碳腈的水解或硫代水解制备，或在硫代羧酰胺的情况下，通过4-羧酰胺与五硫化二磷的反应制备。
• US4008250A
  申请人：——

  公开号：US4008250A

  公开（公告）日：1977-02-15