5-amino-N-(4-methoxyphenyl)-3,4-diphenylthieno[2,3-c]pyridazine-6-carboxamide | 299464-88-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-amino-N-(4-methoxyphenyl)-3,4-diphenylthieno[2,3-c]pyridazine-6-carboxamide
• CAS: 299464-88-3
• 化学式: C₂₆H₂₀N₄O₂S
• 分子量: 452.536
• InChiKey: RLWNIUBSCXWLMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  118
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  5-amino-N-(4-methoxyphenyl)-3,4-diphenylthieno[2,3-c]pyridazine-6-carboxamide 在 溶剂黄146 、 sodium nitrite 作用下， 反应 9.0h， 以72%的产率得到5-(4-Methoxyphenyl)-12,13-diphenyl-8-thia-3,4,5,10,11-pentazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,9,11-pentaen-6-one
  参考文献：
  名称：

  SYNTHESIS OF PYRIDAZOTHIENOTHIAZINE AND PYRIMIDOTHIENOPYRIDAZINES

  摘要：

  3-amino-4,5-diphenylthieno[2, 3-c]pyridazine-2-arylcarboxamide 2 underwent cyclization with triethyl orthoformate and with nitrous acid to give the pyrimidothienopyridazines 3a-c, 4b respectively. 3-amino-4,5-diphenylthieno [2,3-c] pyridazine-2-carbohydrazide 6 reacted with aromatic aldehydes to give;the corresponding carbohydrazones 7a-c. Compound 7 reacts with triethyl orthoformate, acetic anhydride or with CS2/pyridine to produce pyrimidothienopyridazines 8,9 and pyridazothienothiazine 11.

  DOI：

  10.1080/10426500008045255
• 作为产物：
  描述：

  4-cyano-5,6-diphenylpyridazine-3 (2H)-thione 、 2-氯-N-(4-甲氧基苯基)-乙酰胺 在 potassium carbonate 作用下， 以 乙醇 为溶剂， 反应 2.0h， 生成 5-amino-N-(4-methoxyphenyl)-3,4-diphenylthieno[2,3-c]pyridazine-6-carboxamide
  参考文献：
  名称：

  SYNTHESIS OF PYRIDAZOTHIENOTHIAZINE AND PYRIMIDOTHIENOPYRIDAZINES

  摘要：

  3-amino-4,5-diphenylthieno[2, 3-c]pyridazine-2-arylcarboxamide 2 underwent cyclization with triethyl orthoformate and with nitrous acid to give the pyrimidothienopyridazines 3a-c, 4b respectively. 3-amino-4,5-diphenylthieno [2,3-c] pyridazine-2-carbohydrazide 6 reacted with aromatic aldehydes to give;the corresponding carbohydrazones 7a-c. Compound 7 reacts with triethyl orthoformate, acetic anhydride or with CS2/pyridine to produce pyrimidothienopyridazines 8,9 and pyridazothienothiazine 11.

  DOI：

  10.1080/10426500008045255

文献信息

• SYNTHESIS OF PYRIDAZOTHIENOTHIAZINE AND PYRIMIDOTHIENOPYRIDAZINES
  作者：Sh. M. Radwan、A. M. Kamal El-Dean

  DOI：10.1080/10426500008045255

  日期：2000.1

  3-amino-4,5-diphenylthieno[2, 3-c]pyridazine-2-arylcarboxamide 2 underwent cyclization with triethyl orthoformate and with nitrous acid to give the pyrimidothienopyridazines 3a-c, 4b respectively. 3-amino-4,5-diphenylthieno [2,3-c] pyridazine-2-carbohydrazide 6 reacted with aromatic aldehydes to give;the corresponding carbohydrazones 7a-c. Compound 7 reacts with triethyl orthoformate, acetic anhydride or with CS2/pyridine to produce pyrimidothienopyridazines 8,9 and pyridazothienothiazine 11.