(2-Phenylallyl)hydrazine | 65814-30-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-Phenylallyl)hydrazine
• 英文别名: 2-phenylprop-2-enylhydrazine
• CAS: 65814-30-4
• 化学式: C₉H₁₂N₂
• 分子量: 148.2
• InChiKey: IHEVYQFGSZLVRV-UHFFFAOYSA-N

物化性质

• 沸点：
  307.5±31.0 °C(Predicted)
• 密度：
  1.003±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-tert-butoxycarbonyl-N'-(2-phenylallyl)hydrazine 、 盐酸 、 、 (2-Phenylallyl)hydrazine 在 氮 、 甲醇 、 乙醚 作用下， 以 乙醚 为溶剂， 反应 8.0h， 以A white crystalline solid was obtained (0.36 g, 48%)的产率得到(3-phenylpropyl)hydrazine hydrochloride
  参考文献：
  名称：

  Inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and VAP-1 mediated adhesion useful for treatment of diseases

  摘要：

  本发明提供了用于治疗炎症性疾病和免疫紊乱的组合物及其使用方法。本发明揭示了烯丙基肼化合物、羟胺（氨氧）化合物和其他化合物，它们是半卡巴肼敏感胺氧化酶（SSAO）和/或血管黏附蛋白1（VAP-1）的抑制剂。这些化合物在抑制炎症和炎症反应以及治疗多种疾病，包括多发性硬化症方面具有治疗效用。

  公开号：

  US20050096360A1

文献信息

• Inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and VAP-1 mediated adhesion useful for treatment and prevention of diseases
  申请人：Wang Yanjun Eric

  公开号：US20070293548A1

  公开（公告）日：2007-12-20

  Compositions and methods of using compositions for treatment of inflammatory diseases and immune disorders are provided. Allylamino compounds are disclosed which are inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and/or vascular adhesion protein 1 (VAP-1). The compounds have therapeutic utility in suppressing inflammation and inflammatory responses, and in treatment of several disorders, including multiple sclerosis and stroke.

  提供了用于治疗炎症性疾病和免疫紊乱的组合物及使用组合物的方法。公开了一种烯丙胺化合物，它们是半胱氨酸敏感胺氧化酶（SSAO）和/或血管粘附蛋白1（VAP-1）的抑制剂。这些化合物在抑制炎症和炎症反应方面具有治疗效用，并可用于治疗多发性硬化症和中风等多种疾病。
• Amine-based and amide-based inhibitors of semicarbazide-sensitive amine oxidase (SSAO) enzyne activity and VAP-1 mediated adhesion useful for treatment of diseases
  申请人：Salter-Cid M. Luisa

  公开号：US20060025438A1

  公开（公告）日：2006-02-02

  Compositions and methods are disclosed for inhibiting semicarbazide-sensitive amine oxidase (SSAO), also known as vascular adhesion protein-1 (VAP-1). The compounds disclosed are amine-containing and amide-containing compounds. The compounds and compositions are useful for treatment of diseases, including inflammation, inflammatory diseases and autoimmune disorders.

  本发明揭示了一种抑制半卡巴肼敏感性胺基氧化酶（SSAO）的化合物和方法，SSAO也被称为血管黏附蛋白-1（VAP-1）。所揭示的化合物为含有胺基和酰胺基的化合物。这些化合物和组合物对于治疗炎症、炎症性疾病和自身免疫性疾病等疾病是有用的。
• Amine-based and amide-based inhibitors of semicarbazide-sensitive amine oxidase (SSAO)enzyme activity and VAP-1 mediated adhesion useful for treatment of diseases
  申请人：Salter-Cid M. Luisa

  公开号：US20070078157A1

  公开（公告）日：2007-04-05

  Compositions and methods are disclosed for inhibiting semicarbazide-sensitive amine oxidase (SSAO), also known as vascular adhesion protein-1 (VAP-1). The compounds disclosed are amine-containing and amide-containing compounds. The compounds and compositions are useful for treatment of diseases, including inflammation, inflammatory diseases and autoimmune disorders.

  本发明公开了抑制半卡巴肼敏感性胺氧化酶（SSAO），也称为血管黏附蛋白-1（VAP-1）的组合物和方法。所公开的化合物是含有胺基和酰胺基的化合物。这些化合物和组合物可用于治疗炎症、炎症性疾病和自身免疫性疾病等疾病。
• INHIBITORS OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) AND VAP-1 MEDIATED ADHESION USEFUL FOR TREATMENT AND PREVENTION OF DISEASES
  申请人：WANG Eric Yanjun

  公开号：US20110269811A1

  公开（公告）日：2011-11-03

  Compositions and methods of using compositions for treatment of inflammatory diseases and immune disorders are provided. Allylamino compounds are disclosed which are inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and/or vascular adhesion protein 1 (VAP-1). The compounds have therapeutic utility in suppressing inflammation and inflammatory responses, and in treatment of several disorders, including multiple sclerosis and stroke.

  提供了治疗炎症性疾病和免疫紊乱的组合物和使用组合物的方法。披露了抑制半胱氨酸敏感胺氧化酶（SSAO）和/或血管黏附蛋白1（VAP-1）的丙烯氨基化合物。这些化合物在抑制炎症和炎症反应以及治疗多种疾病，包括多发性硬化和中风方面具有治疗效用。
• AMINE-BASED AND AMIDE-BASED INHIBITORS OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) ENZYME ACTIVITY AND VAP-1 MEDIATED ADHESION USEFUL FOR TREATMENT OF DISEASES
  申请人：SALTER-CID LUISA M.

  公开号：US20120172392A1

  公开（公告）日：2012-07-05

  Compositions and methods are disclosed for inhibiting semicarbazide-sensitive amine oxidase (SSAO), also known as vascular adhesion protein-1 (VAP-1). The compounds disclosed are amine-containing and amide-containing compounds. The compounds and compositions are useful for treatment of diseases, including inflammation, inflammatory diseases and autoimmune disorders.

  本文揭示了一种抑制半卡巴肼敏感性胺氧化酶（SSAO），也称为血管粘附蛋白-1（VAP-1）的组合物和方法。所揭示的化合物包括含胺和含酰胺的化合物。这些化合物和组合物对于治疗疾病，包括炎症、炎症性疾病和自身免疫性疾病非常有用。