4-(methoxymethoxy)-4'-methoxybiphenyl | 1345981-29-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(methoxymethoxy)-4'-methoxybiphenyl
• 英文别名: 1-Methoxy-4-[4-(methoxymethoxy)phenyl]benzene
• CAS: 1345981-29-4
• 化学式: C₁₅H₁₆O₃
• 分子量: 244.29
• InChiKey: AVJHNMHDGZTXQQ-UHFFFAOYSA-N

物化性质

• 沸点：
  375.9±37.0 °C(Predicted)
• 密度：
  1.082±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-氯-4-(甲氧基甲氧基)苯 、 4-甲氧基苯基溴化镁 在 ((C₆H₄)(PPh₂)(NCHPhP(O)Ph₂))NiCl 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以80%的产率得到4-(methoxymethoxy)-4'-methoxybiphenyl
  参考文献：
  名称：

  Kumada Coupling of Aryl, Heteroaryl, and Vinyl Chlorides Catalyzed by Amido Pincer Nickel Complexes

  摘要：

  A series of amido pincer complexes of nickel were examined for their catalysis in the Kumada cross-coupling reaction. The P,N,O-pincer nickel complexes tested are active catalysts for the cross-coupling of aryl, heteroaryl, and vinyl chlorides with aryl Grignard reagents. The reactions can proceed at room temperature and tolerate functional groups in aryl chlorides with the aid of LiCl and ZnCl2 additives.

  DOI：

  10.1021/jo201821g

文献信息

• Kumada Coupling of Aryl, Heteroaryl, and Vinyl Chlorides Catalyzed by Amido Pincer Nickel Complexes
  作者：Ning Liu、Zhong-Xia Wang

  DOI：10.1021/jo201821g

  日期：2011.12.16

  A series of amido pincer complexes of nickel were examined for their catalysis in the Kumada cross-coupling reaction. The P,N,O-pincer nickel complexes tested are active catalysts for the cross-coupling of aryl, heteroaryl, and vinyl chlorides with aryl Grignard reagents. The reactions can proceed at room temperature and tolerate functional groups in aryl chlorides with the aid of LiCl and ZnCl2 additives.