3-{4-[3-(dimethylamino)propoxy]phenyl}-2-phenyl-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile trifluoroacetate | 664990-83-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 3-{4-[3-(dimethylamino)propoxy]phenyl}-2-phenyl-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile trifluoroacetate
• 英文别名: 3-[4-[3-(dimethylamino)propoxy]phenyl]-2-phenyl-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile;2,2,2-trifluoroacetic acid
• CAS: 664990-83-4
• 化学式: C₂HF₃O₂*C₂₅H₂₄N₄O
• 分子量: 510.516
• InChiKey: VIAKMTBFQAWUGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.73
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• Tricyclic compounds and method of treating herpes virus
  申请人：——

  公开号：US20030229073A1

  公开（公告）日：2003-12-11

  The present invention provides a compound of the formula (I) and pharmaceutically acceptable salts having useful antiviral activity against viruses of the herpes family. In said formula, X=O, (CH 2 ) m , S, SO, SO 2 , NH, NR 8 or a chemical bond; Y=O, (CH 2 ) m , S, SO, SO 2 , NH, NR 8 ; Z=NH, O, NR 8 , S, SO, SO 2 . The remaining substituents are described in the specification.

  本发明提供了一种公式(I)的化合物及其药学上可接受的盐，对于单纯疱疹病毒家族的病毒具有有用的抗病毒活性。在该式中，X=O、(CH2)m、S、SO、SO2、NH、NR8或化学键；Y=O、( )m、S、SO、SO2、NH、NR8；Z=NH、O、NR8、S、SO、SO2。其余的取代基在说明书中描述。
• Substituted pyrrolopyridines
  申请人：Nielsen Aadal Peter

  公开号：US20050261331A1

  公开（公告）日：2005-11-24

  There are provided novel compounds of formula (I) wherein R 1 , R 2 and R 3 are as defined in the specification and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the kinase Itk.

  提供了公式（I）的新化合物，其中R1、R2和R3如规范中定义，并且其药学上可接受的盐；以及它们的制备过程、含有它们的组合物和它们在治疗中的用途。这些化合物是Itk激酶的抑制剂。
• TRICYCLIC COMPOUNDS WITH ANTIVIRAL ACTIVITY
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1248777A2

  公开（公告）日：2002-10-16
• Tricyclic compounds with antiviral activity
  申请人：Booth John Richard

  公开号：US20050075332A1

  公开（公告）日：2005-04-07

  The present invention provides a compound of the formula (I) and pharmaceutically acceptable salts having useful antiviral activity against viruses of the herpes family. In said formula, X═O, (CH 2 ) m , S, SO, SO 2 , NH, NR 8 , or a chemical bond; Y═O, (CH 2 ) m , S, SO, SO 2 , NH, NR 8 ; Z=NH, O, NR 8 , S, SO, SO 2 . The remaining substituents are described in the specification.
• US6800656B2
  申请人：——

  公开号：US6800656B2

  公开（公告）日：2004-10-05