N-[(3-iodophenyl)methyl-oxo-phenyl-lambda6-sulfanylidene]-4-methylbenzenesulfonamide | 470475-52-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[(3-iodophenyl)methyl-oxo-phenyl-lambda6-sulfanylidene]-4-methylbenzenesulfonamide
• 英文别名: N-[(3-iodophenyl)methyl-oxo-phenyl-λ6-sulfanylidene]-4-methylbenzenesulfonamide
• CAS: 470475-52-6
• 化学式: C₂₀H₁₈INO₃S₂
• 分子量: 511.404
• InChiKey: IZVIWHGXPYWERS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  80.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-[(3-iodophenyl)methyl-oxo-phenyl-lambda6-sulfanylidene]-4-methylbenzenesulfonamide 在 四(三苯基膦)钯 copper(l) iodide 、 二异丙胺 作用下， 以 甲苯 为溶剂， 反应 12.0h， 生成 88,91-Diazapentadecacyclo[81.3.1.126,30.133,37.140,44.169,73.176,80.04,13.07,12.014,23.015,20.047,56.050,55.057,66.058,63]dononaconta-1(87),4(13),5,7,9,11,14(23),15,17,19,21,26(92),27,29,33(91),34,36,40,42,44(90),47(56),48,50,52,54,57(66),58,60,62,64,69(89),70,72,76,78,80(88),83,85-octatriacontaen-2,24,31,38,45,67,74,81-octayne
  参考文献：
  名称：

  Sulfoximine Version of Double Elimination Protocol for Synthesis of Chiral Acetylenic Cyclophanes

  摘要：

  A new strategy for constructing enantiopure acetylenic cyclophanes is described on the basis of one-pot double elimination reaction starting from dialdehydes and bis(sulfoximine)s. In this case, the conventional sulfone protocol affords poorer yields of the desired cyclophanes. Thus, arylene-ethynylene moieties with terminal sulfoximine or formyl functions are linked to binaphthyl cores and these building blocks are then subjected to double elimination reaction. The desired macrocycles are obtained in up to 35% yield. The corresponding Sonogashira coupling fails to afford cyclophanes indicative of effectiveness of the double elimination methodology.

  DOI：

  10.1002/1521-3765(20020503)8:9<2005::aid-chem2005>3.0.co;2-i
• 作为产物：
  描述：

  3-碘苯甲醇 在 ruthenium(IV) oxide 、 sodium periodate 、 三丁基膦 、 十六烷基三丁基溴化磷 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 9.0h， 生成 N-[(3-iodophenyl)methyl-oxo-phenyl-lambda6-sulfanylidene]-4-methylbenzenesulfonamide
  参考文献：
  名称：

  Sulfoximine Version of Double Elimination Protocol for Synthesis of Chiral Acetylenic Cyclophanes

  摘要：

  A new strategy for constructing enantiopure acetylenic cyclophanes is described on the basis of one-pot double elimination reaction starting from dialdehydes and bis(sulfoximine)s. In this case, the conventional sulfone protocol affords poorer yields of the desired cyclophanes. Thus, arylene-ethynylene moieties with terminal sulfoximine or formyl functions are linked to binaphthyl cores and these building blocks are then subjected to double elimination reaction. The desired macrocycles are obtained in up to 35% yield. The corresponding Sonogashira coupling fails to afford cyclophanes indicative of effectiveness of the double elimination methodology.

  DOI：

  10.1002/1521-3765(20020503)8:9<2005::aid-chem2005>3.0.co;2-i