optically inactive 2,3-diethyl-2,3-diisopropyl-succinic acid | 100912-67-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: optically inactive 2,3-diethyl-2,3-diisopropyl-succinic acid
• 英文别名: Opt.-inakt. 2,3-Diaethyl-2,3-diisopropyl-bernsteinsaeure；2,3-Diethyl-2,3-di(propan-2-yl)butanedioic acid
• CAS: 100912-67-2
• 化学式: C₁₄H₂₆O₄
• 分子量: 258.358
• InChiKey: FUFSLRDLUNRCHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氢氧化钾 作用下， 生成 optically inactive 2,3-diethyl-2,3-diisopropyl-succinic acid
  参考文献：
  名称：

  Benzodiazepines and anterior pituitary function

  摘要：

  Benzodiazepines (BDZ) are one of the most prescribed classes of drugs because of their marked anxiolytic, anticonvulsant, muscle relaxant and hypnotic effects. The pharmacological actions of BDZ depend on the activation of 2 specific receptors. The central BDZ receptor, present in several areas of the central nervous system (CNS), is a component of the GABA-A receptor, the activation of which increases GABAergic neurotransmission and is followed by remarkable neuroendocrine effects. The peripheral benzodiazepine receptors (PBR), structurally and functionally different from the GABA-A receptor, have been shown in peripheral tissues but also in the CNS, in both neurones and glial cells, and in the pituitary gland. BDZ receptors bind to a family of natural peptides called endozepines, firstly isolated from neurons and glial cells in the brain and then in several peripheral tissues as well. Endozelpines modulate several central and peripheral biological activities, including some neuroendocrine functions and synthetic BDZ are likely to mimic them, at least partially. BZD, especially alprazolam (AL), possess a clear inhibitory influence on the activity of the HPA axis in both animals and humans. This effect seems to be mediated at the hypothalamic and/or suprahypothalamic level via suppression of CRH. The strong negative influence of AL on hypothalamic-pituitary-adrenal (HPA) axis agrees with its peculiar efficacy in the treatment of panic disorders and depression. BZD have also been shown to increase GH secretion via mechanisms mediated at the hypothalamic or supra-hypothalamic level, though a pituitary action cannot be ruled out. Besides the impact on HPA and somatotrope function, BDZ also significantly affect the secretion of other pituitary hormones, such as gonadotropins and. PRL, probably acting through GABAergic mediation in the hypothalamus and/or in the pituitary gland. In all, BDZ are likely to represent a useful tool to investigate GABAergic activity and clarify its role in the neuroendocrine control of anterior pituitary function; their usefulness probably overrides what had been supposed before.

  DOI：

  10.1007/bf03345110

文献信息

• Catalyst composition for the copolymerization of propylene
  申请人：TOTAL PETROCHEMICALS RESEARCH FELUY

  公开号：EP1849807A1

  公开（公告）日：2007-10-31

  The present invention relates to a process for the production of propylene polymers in the presence of a Ziegler-Natta catalyst comprising a titanium compound having at least one titanium-halogen bond, and a blend of a diether compound and a succinate compound as internal electron donor, all supported on a magnesium halide in active form, an organoaluminium compound and an optional external donor.

  本发明涉及一种在齐格勒-纳塔催化剂存在下生产丙烯聚合物的工艺，齐格勒-纳塔催化剂包括至少有一个钛-卤素键的钛化合物，以及作为内部电子供体的二醚化合物和琥珀酸化合物的混合物，所有这些催化剂都支撑在活性形式的卤化镁、有机铝化合物和任选的外部供体上。
• MANUFACTURING METHOD OF SOLID CATALYST FOR PROPYLENE POLYMERIZATION
  申请人：Samsung Total Petrochemicals Co. Ltd.

  公开号：EP2511303A2

  公开（公告）日：2012-10-17

  Disclosed is a method for preparing a solid catalyst for propylene polymerization, specifically to a method for preparing a solid catalyst for propylene polymerization which can produce a polypropylene having high melt flow rate, a wide molecular distribution and excellent stereoregularity with a high production yield.

  本发明公开了一种丙烯聚合用固体催化剂的制备方法，特别是一种丙烯聚合用固体催化剂的制备方法，该方法可以生产出熔体流动速率高、分子分布广、立体规整性好、产量高的聚丙烯。
• Solid catalyst component for use in olefin polymerisation, catalyst, and application thereof
  申请人：BEIJING LIHE TECHNOLOGY LTD

  公开号：US11136421B2

  公开（公告）日：2021-10-05

  Provided in the present invention is a solid catalyst component for use in olefin polymerisation, comprising Mg, Ti, a halogen, and at least one electron donor, the electron donor being a 2-substituted amino-phenyl ester compound selected from general formula (I). Also disclosed in the present invention are a catalyst comprising the solid catalyst component, and an application for the catalyst in olefin polymerisation, particularly in propylene polymerization. Also provided in the present invention is a high activity catalyst, said catalyst being able to obtain polypropylene of high isotacticity and wide molecular weight distribution, and not requiring an external electron donor to obtain high isotacticity polypropylene; during polymerization, Al/Ti and Al/Si are reduced, the polymerization time is lengthened, and high activity can still be maintained, suitable for producing low-ash polymers.

  本发明提供了一种用于烯烃聚合的固体催化剂组分，包括 Mg、Ti、卤素和至少一种电子供体，电子供体为选自通式 (I) 的 2-取代氨基苯基酯化合物。本发明还公开了一种包含固体催化剂组分的催化剂，以及该催化剂在烯烃聚合，特别是丙烯聚合中的应用。本发明还提供了一种高活性催化剂，所述催化剂能够获得高同素异形度和宽分子量分布的聚丙烯，并且不需要外部电子供体即可获得高同素异形度聚丙烯；在聚合过程中，Al/Ti 和 Al/Si 降低，聚合时间延长，仍可保持高活性，适用于生产低灰分聚合物。
• Polypropylene composition and molded article
  申请人：BASELL POLIOLEFINE ITALIA S.R.L.

  公开号：US11319431B2

  公开（公告）日：2022-05-03

  A polypropylene composition made from or containing (i) component (1) made from or containing a propylene homopolymer or copolymer containing 0 to 0.5% by weight of an ethylene-derived unit; (ii) component (2) made from or containing an ethylene/propylene copolymer containing 15 to 30% by weight of an ethylene-derived unit; and (iii) 0.01 to 1.0 parts by weight of a crystal nucleating agent based on a total of 100 parts by weight of component (1) and component (2); wherein 1) the Mw/Mn value of xylene insolubles (XI) is in the range of 6 to 20, 2) the weight ratio of component (1) to component (2) is in the range of 82:18 to 90:10, 3) the intrinsic viscosity of xylene solubles (XSIV) is in the range of 2.5 to 3.4 dl/g, 4) the MFR (at 230° C. under a load of 2.16 kg) is in the range of 3 to 10 g/10 min.

  一种聚丙烯组合物，由以下成分制成或包含以下成分： (i) 成分(1)，由或包含聚丙烯均聚物或共聚物制成，所述共聚物包含0到0.5%质量百分比的乙烯基单元； (ii) 成分(2)，由或包含乙烯/丙烯共聚物制成，所述共聚物包含15到30%质量百分比的乙烯基单元；以及 (iii) 基于成分(1)和成分(2)总质量为100质量份时的0.01到1.0质量份的晶核剂； 其中： 1) 二甲苯不溶物(XI)的Mw/Mn值在6到20的范围内， 2) 成分(1)与成分(2)的质量比在82:18到90:10的范围内， 3) 二甲苯可溶物(XSIV)的特性粘度在2.5到3.4 dl/g的范围内， 4) 熔体流动速率(MFR)(在230°C及2.16 kg负荷下)在3到10 g/10分钟的范围内。
• High melt strength polypropylene and extrusion process for preserving melt strength
  申请人：EXXONMOBIL CHEMICAL PATENTS INC.

  公开号：US11414526B2

  公开（公告）日：2022-08-16

  A method of melt blending a polypropylene and the melt blended polypropylene therefrom, comprising providing a base-polypropylene having a MFR of less than 15 g/10 min and a molecular weight distribution (Mw/Mn) within the range from 5 to 16, and comprising hindered phenol and phosphorous-type antioxidants, and within the range from 5 ppm to 4000 ppm of an alkyl radical scavenger relative to the total weight of the components to form a melt blended polypropylene; melt blending the melt blended polypropylene at a temperature of at least 210° C.; and isolating a melt blended, melt blended polypropylene.

  一种熔融共混聚丙烯及其熔融共混聚丙烯的方法，包括提供一种碱基聚丙烯，其 MFR 小于 15 g/10min，分子量分布（Mw/Mn）在 5 至 16 范围内，并包含受阻酚类和磷类抗氧化剂，以及相对于组分总重量在 5 ppm 至 4000 ppm 范围内的烷基自由基清除剂，以形成熔融共混聚丙烯；在至少 210°C 的温度下熔融混合熔融混合聚丙烯；以及分离熔融共混聚丙烯。