N-carbamimidoyl-sulfanilic acid amide; hydrochloride | 112677-51-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-carbamimidoyl-sulfanilic acid amide; hydrochloride
• 英文别名: N-Carbamimidoyl-sulfanilsaeure-amid; Hydrochlorid；4-guanidino-benzenesulfonamide hydrogen chloride；4-Guanidinobenzenesulfonamide hydrochloride；2-(4-sulfamoylphenyl)guanidine;hydrochloride
• CAS: 112677-51-7
• 化学式: C₇H₁₀N₄O₂S*ClH
• 分子量: 250.709
• InChiKey: SIHCHPRMFQXMPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.64
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  133
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (5-dimethylaminomethylene-2-(3-methoxyphenyl)-6,7-dihydro-5H-benzo[b]thiophen-4-one) 、 N-carbamimidoyl-sulfanilic acid amide; hydrochloride 在 potassium carbonate 作用下， 以 2,4-滴二甲胺盐 为溶剂， 反应 12.0h， 生成 4-[8-(3-Methoxyphenyl)-5,6-dihydro-thieno[2,3-h]quinazolin-2-ylamino)-benzenesulfonamide
  参考文献：
  名称：

  Compositions useful as inhibitors of protein kinases

  摘要：

  本发明涉及作为蛋白激酶抑制剂有用的化合物。该发明还提供了制备这些化合物的方法，包括这些化合物的药用可接受组合物，以及在治疗各种疾病、症状或障碍中使用这些化合物和组合物的方法。

  公开号：

  US20050148603A1
• 作为产物：
  描述：

  氰胺 、 磺胺 在 盐酸 作用下， 反应 0.25h， 生成 N-carbamimidoyl-sulfanilic acid amide; hydrochloride
  参考文献：
  名称：

  Preparation of substituted N-phenyl-4-aryl-2-pyrimidinamines as mediator release inhibitors

  摘要：

  The role of immunologically released mediators, such as histamine, leukotrienes, and platelet-activating factor, is well-established for asthma and other allergic disorders. Developing therapeutic agents which would block mediator release from mast cells and other relevant cell types would provide a rational approach to asthma therapy. Using human basophil as a screen, a series of 4-aryl-2-(phenylamino)pyrimidines was found which inhibited mediator release. These compounds were prepared by condensing acetyl heterocycles with dimethylformamide dimethyl acetal to form enaminones which are cyclized with aryl guanidines to give pyrimidines. After examining a large number of analogs, N-[3-(1H-imidazol-1-yl)phenyl]-4-(2-pyridinyl)-2-pyrimidinamine (1-27) was chosen for toxicological evaluation.

  DOI：

  10.1021/jm00071a002

文献信息

• [EN] KINASE INHIBITORS AND THEIR USE AS PHARMACEUTICAL AGENTS<br/>[FR] INHIBITEURS DE KINASE ET LEUR UTILISATION EN TANT QU'AGENTS PHARMACEUTIQUES
  申请人：SHANGHAI GENOMICS INC

  公开号：WO2010051781A1

  公开（公告）日：2010-05-14

  Described herein are compounds that are inhibitors of one or more protein kinases. Also described are pharmaceutical compositions and medicaments that include the compounds described herein. Also described herein are methods of using such protein kinase inhibitors, alone and in combination with other compounds, for conditions or diseases mediated or dependent upon protein kinases.

  本文描述了一些抑制一个或多个蛋白激酶的化合物。还描述了包括本文所述化合物的药物组合物和药物。本文还描述了使用这些蛋白激酶抑制剂的方法，单独或与其他化合物结合，用于受蛋白激酶介导或依赖的疾病或病症。
• KINASE INHIBITORS AND THEIR USE AS PHARMACEUTICAL AGENTS
  申请人：LUO Ying

  公开号：US20110263541A1

  公开（公告）日：2011-10-27

  Described herein are compounds that are inhibitors of one or more protein kinases. Also described are pharmaceutical compositions and medicaments that include the compounds described herein. Also described herein are methods of using such protein kinase inhibitors, alone and in combination with other compounds, for conditions or diseases mediated or dependent upon protein kinases.

  本文描述了一些抑制一个或多个蛋白激酶的化合物。还描述了包括本文描述的化合物的药物组合物和药物。本文还描述了使用这种蛋白激酶抑制剂的方法，单独或与其他化合物结合，用于受蛋白激酶介导或依赖的疾病或病症。
• COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES
  申请人：Jimenez Juan-Miguel

  公开号：US20100280026A1

  公开（公告）日：2010-11-04

  The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides processes for preparing the compounds, pharmaceutically acceptable compositions comprising the compounds, and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders.

  本发明涉及作为蛋白激酶抑制剂有用的化合物。该发明还提供了制备这些化合物的方法，包括这些化合物的药学上可接受的组合物，以及使用这些化合物和组合物治疗各种疾病、状况或障碍的方法。
• US7700609B2
  申请人：——

  公开号：US7700609B2

  公开（公告）日：2010-04-20
• US8017619B2
  申请人：——

  公开号：US8017619B2

  公开（公告）日：2011-09-13