Dimethyl (3S,4S)-pyrrolidine-3,4-dicarboxylate | 111138-53-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: Dimethyl (3S,4S)-pyrrolidine-3,4-dicarboxylate
• CAS: 111138-53-5
• 化学式: C₈H₁₃NO₄
• 分子量: 187.196
• InChiKey: DEONENFBMPLKOR-PHDIDXHHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Dimethyl (3S,4S)-pyrrolidine-3,4-dicarboxylate 、 溴甲苯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 20.0h， 以76%的产率得到dimethyl trans-1-benzylpyrrolidine-3,4-dicarboxylate
  参考文献：
  名称：

  酶和催化剂。I.猪肝酯酶催化的杂环二酯的水解。

  摘要：

  五元环二酯的不对称水解是通过使用猪肝酯酶（PLE）作为催化剂进行的。得到的半酯和回收的二酯的绝对构型被确立，并揭示了PLE在此类体系中的立体特异性。

  DOI：

  10.1248/cpb.35.2266
• 作为产物：
  描述：

  trans-3,4-dicarbomethoxypyrrolidine 以26%的产率得到
  参考文献：
  名称：

  MORIMOTO, YOSHIHISA;TERAO, YOSHIYASU;ACHIWA, KAZUO, CHEM. AND PHARM. BULL., 35,(1987) N 6, 2266-2271

  摘要：

  DOI：

文献信息

• Lipophilic oxadiazoles
  申请人：MERCK SHARP & DOHME LTD.

  公开号：EP0323864A2

  公开（公告）日：1989-07-12

  Oxadiazoles of formula I wherein one of X, Y and Z is an oxygen atom and the other two are nitrogen atoms, and the dotted circle represents aromaticity (two double bonds) thus forming a 1,3,4-oxadiazole or 1,2,4-oxadiazole nucleus; R¹ represents a non-aromatic azacyclic or azabicyclic ring system; and R² represents an optionally substituted saturated hyrocarbon group having at least three carbon atoms, or unsaturated hydrocarbon group having at least 6 carbon atoms, have particularly advantageous selective properties for use in the treatment and/or prevention of neurodegenerative diseases.

  式 I 的噁二唑 其中，X、Y 和 Z 中的一个是氧原子，另外两个是氮原子，圆点代表芳香性（两个双键），从而形成 1，3，4-噁二唑或 1，2，4-噁二唑核；R¹ 代表非芳香的氮杂环或氮杂环环系；R²代表至少有三个碳原子的任选取代饱和烃基，或至少有六个碳原子的不饱和烃基，具有特别有利的选择性，可用于治疗和/或预防神经退行性疾病。
• Pyrazines, pyrimidines and pyridazines, useful in the treatment of senile dementia
  申请人：MERCK SHARP & DOHME LTD.

  公开号：EP0327155A2

  公开（公告）日：1989-08-09

  The present invention provides pyrazines, pyridazines or pyrimidines, or salts or prodrugs thereof, substituted on one of the ring carbon atoms therefore with a non-aromatic azacyclic or azabicyclic ring system; and independently substituted on each of the other ring carbon atoms with a substituent of low lipophilicity or a hydrocarbon substituent; which compounds stimulate central muscarinic acetylcholine receptors and therefore are useful in the treatment of neurological and mental illnesses.

  本发明提供吡嗪类、哒嗪类或嘧啶类化合物，或其盐类或原药，其中一个环碳原子被非芳族氮杂环或氮杂环环系取代；其他每个环碳原子分别独立地被低亲脂性取代基或烃类取代基取代；这些化合物可刺激中枢毒蕈碱乙酰胆碱受体，因此可用于治疗神经和精神疾病。
• Catalysts and methods for epoxide-based polymerizations
  申请人：Cornell University

  公开号：US11260379B2

  公开（公告）日：2022-03-01

  Provided are catalysts, methods of making catalysts, methods of using catalysts, and copolymers made utilizing the catalysts. The catalyst has a metal salen complex group, a bridging group, and one or more co-catalyst groups. The metal salen complex group is attached to the bridging group and the bridging group is attached to the co-catalyst group. The copolymers made utilizing the catalysts are polyesters or polycarbonates.

  本文提供了催化剂、催化剂的制造方法、催化剂的使用方法以及利用催化剂制造的共聚物。催化剂具有金属沙伦络合物基团、桥接基团和一个或多个助催化剂基团。金属沙伦络合物基团与桥接基团相连，桥接基团与助催化剂基团相连。利用催化剂制成的共聚物是聚酯或聚碳酸酯。
• Chemoenzymatic preparation of non-racemic N-Boc-pyrrolidine-3,4-dicarboxylic acid 3-ethyl esters and their 4-hydroxymethyl derivatives
  作者：Rosa Marı́a Rodrı́guez Sarmiento、Beat Wirz、Hans Iding

  DOI：10.1016/s0957-4166(03)00284-2

  日期：2003.6

  For the synthesis of metalloproteinase inhibitors the (R,R)- and (S,S)-monoethyl esters of N-Boe-pyrrolidine-3,4-dicarboxylic acid were prepared as key intermediates from the trans-diester racemate by two consecutive, highly selective enzymatic reactions. Reduction of the formed acids to the corresponding enantiopure hydroxymethyl derivatives ((R,R)- and (S,S)-ethyl N-Boc-4-hydroxymethyl-3-carboxylate) gives access to a new series of chiral building blocks. (C) 2003 Elsevier Science Ltd. All rights reserved.
• Oxadiazolyl-azabicycloheptanes for the treatment of senile dementia
  申请人：MERCK SHARP & DOHME LTD.

  公开号：EP0307140B1

  公开（公告）日：1994-03-02