5-fluoro-6-(7-methylpyrazolo[1,5-a]pyridin-3-yl)-2H-pyrazolo[3,4-b]pyridin-3-amine | 1134614-78-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-fluoro-6-(7-methylpyrazolo[1,5-a]pyridin-3-yl)-2H-pyrazolo[3,4-b]pyridin-3-amine
• CAS: 1134614-78-0
• 化学式: C₁₄H₁₁FN₆
• 分子量: 282.28
• InChiKey: IOQNPLDRPYJVFU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  84.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-溴丁酸 、 5-fluoro-6-(7-methylpyrazolo[1,5-a]pyridin-3-yl)-2H-pyrazolo[3,4-b]pyridin-3-amine 在 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 生成 2-(3-amino-5-fluoro-6-(7-methyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)ethyl acetate
  参考文献：
  名称：

  NOVEL COMPOUNDS HAVING INDAZOLE FRAMEWORKS, METHODS FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

  摘要：

  提供了具有吲唑骨架的新化合物，以及制备这些化合物的方法和包含这些化合物的药物组合物。本发明的化合物可以抑制蛋白激酶活性，因此本发明的药物组合物可用于预防或治疗与蛋白激酶活性相关的疾病或障碍。

  公开号：

  US20100256133A1

文献信息

• [EN] NOVEL COMPOUNDS HAVING INDAZOLE FRAMEWORKS, METHODS FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME<br/>[FR] NOUVEAUX COMPOSÉS PRÉSENTANT DES SQUELETTES D'INDAZOLE, MÉTHODES DE PRÉPARATION DE CEUX-CI ET COMPOSITION PHARMACEUTIQUE LES CONTENANT
  申请人：CHOONGWAE PHARMA CORP

  公开号：WO2009038385A3

  公开（公告）日：2009-06-18
• [EN] USE OF PYRAZOLE-PYRIDINE DERIVATIVES AND ITS SALTS FOR TREATING OR REVENTIN OSTEOPOROSIS<br/>[FR] UTILISATION DE DÉRIVÉS PYRAZOLE-PYRIDINE ET DE LEURS SELS POUR LE TRAITEMENT OU LA PRÉVENTION DE L'OSTÉOPOROSE
  申请人：CHOONGWAE PHARMA CORP

  公开号：WO2010027114A1

  公开（公告）日：2010-03-11

  The present invention provides a pharmaceutical composition comprising a pyrazole-pyridine derivative or a pharmaceutically allowable salt thereof for preventing or treating osteoporosis, and particularly relates to a use of a pyrazole-pyridine derivative or a salt thereof that has a bone formation activity by promoting differentiation from a mesenchymal stem cells into osteoblast cells as a preventing or treating agent of bone metabolism diseases, in particular, osteoporosis. The present invention relates to a use of a pyrazole-pyridine derivative or a pharmaceutically allowable salt thereof as an agent for preventing or treating osteoporosis, and the present invention is capable of being used in various diseases that relates to a bone metabolism such as regeneration of the alveolar bone, osteogenesis imperfecta, osteomalacia and the like in addition to prevention or curing effect of osteoporosis.
• NOVEL COMPOUNDS HAVING INDAZOLE FRAMEWORKS, METHODS FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
  申请人：Kim Jeom-Yong

  公开号：US20100256133A1

  公开（公告）日：2010-10-07

  Novel compounds having indazole frameworks, as well as a method for preparing the same and a pharmaceutical composition comprising the same are provided. The compounds of the present invention can inhibit protein kinase activity and thus the pharmaceutical composition of the present invention can be used to prevent or treat diseases or disorders which are related to protein kinase activity.

  提供了具有吲唑骨架的新化合物，以及制备这些化合物的方法和包含这些化合物的药物组合物。本发明的化合物可以抑制蛋白激酶活性，因此本发明的药物组合物可用于预防或治疗与蛋白激酶活性相关的疾病或障碍。