N,N'-Undecamethylen-bis(iodoacetamid) | 19178-39-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N'-Undecamethylen-bis(iodoacetamid)
• 英文别名: 2-iodo-N-[11-[(2-iodoacetyl)amino]undecyl]acetamide
• CAS: 19178-39-3
• 化学式: C₁₅H₂₈I₂N₂O₂
• 分子量: 522.209
• InChiKey: MZUOGNRQWXYXDA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  21
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Alpha-helical mimetics
  申请人：Lessene Guillaume Laurent

  公开号：US20080153802A1

  公开（公告）日：2008-06-26

  Benzoyl urea derivatives that are alpha helical peptides mimetics that mimic BH3-only proteins, compositions containing them, their conjugation to cell-targeting-moieties, and their use in the regulation of cell death are disclosed. The benzoyl urea derivatives are capable of binding to and neutralizing pro-survival Bcl-2 proteins. Use of benzoyl urea derivatives in the treatment and/or prophylaxis of diseases or conditions associated with deregulation of cell death are also described.

  公开了模拟α螺旋肽的苯甲酰脲衍生物，这些衍生物模拟BH3-仅蛋白，含有它们的组合物，它们与细胞靶向基团的结合，以及它们在调节细胞死亡中的用途。苯甲酰脲衍生物能够结合并中和促生存的Bcl-2蛋白。还描述了在治疗和/或预防与细胞死亡失调相关的疾病或症状中使用苯甲酰脲衍生物。
• Antitumor protein hybrid and process for the preparation thereof
  申请人：TEIJIN LIMITED

  公开号：EP0017507A2

  公开（公告）日：1980-10-15

  Antitumor protein hybrid, composed of a moiety which is substantially the fragment Fab of an antitumor immunoglobulin and a moiety which is substantially the fragment A of a diphtheria toxin, which is expressed by the following formula (1): (where Fab indicates a moiety which is substantially the fragment Fab of an antitumor immunoglobulin; FA indicates a moiety which is substantially the fragment A of a diphtheria toxin; X indicates a divalent organic radical; S, and S2 are both sulfur atoms, S, indicating a sulfur atom arising from the disulfide bond (-S-S- bond) in an immunoglobulin and S2 a sulfur atom arising from the disulfide bond in a diphtheria toxin; n stands for 0 or 1 and m stands for an integer of 1 to 5). This antitumor protein hybrid has remarkable and specific citotoxicity against tumor cells.

  抗肿瘤蛋白杂交种，由基本上是抗肿瘤免疫球蛋白的片段 FAb 的分子和基本上是白喉毒素的片段 A 的分子组成，其表达式如下(1)： (其中 FAb 表示基本上是抗肿瘤免疫球蛋白 FAb 片段的分子；FA 表示基本上是白喉毒素 A 片段的分子；X 表示二价有机基；S和S2都是硫原子，S表示免疫球蛋白中二硫键（-S-S-键）产生的硫原子，S2表示白喉毒素中二硫键产生的硫原子；n表示0或1，m表示1至5的整数）。这种抗肿瘤蛋白混合物对肿瘤细胞具有显著的特异性柠檬毒性。
• IMMUNOGENIC WT1 PEPTIDES AND USE THEREOF
  申请人：Memorial Sloan-Kettering Cancer Center

  公开号：EP3520810A2

  公开（公告）日：2019-08-07

  WTl-specific cytotoxic T lymphocytes (CTL), CD8+ lymphocytes or CD4+ lymphocytes, obtained by a method comprising contacting a lymphocyte cell population in vitro or ex vivo with one or more specific WT1 peptides, thereby inducing the formation and proliferation of the WT1-specific lymphocytes, for use in treating a subject with a WT1-expressing cancer or for use in reducing the incidence of a WT1-expressing cancer or its relapse.

  WTl特异性细胞毒性T淋巴细胞（CTL）、CD8+淋巴细胞或CD4+淋巴细胞，其获得方法包括在体外或体内将淋巴细胞群与一种或多种特异性WT1肽接触，从而诱导WT1特异性淋巴细胞的形成和增殖，用于治疗WT1表达癌症患者或用于降低WT1表达癌症的发病率或复发率。
• Immunogenic WT-1 peptides and methods of use thereof
  申请人：Memorial Sloan Kettering Cancer Center

  公开号：US10100087B2

  公开（公告）日：2018-10-16

  This invention provides peptides, immunogenic compositions and vaccines, and methods of treating, reducing the incidence of, and inducing immune responses to a WT-1-expressing cancer, comprising peptides derived from the WT-1 protein.

  本发明提供了多肽、免疫原性组合物和疫苗，以及治疗、降低 WT-1 表达癌症的发病率和诱导对 WT-1 表达癌症的免疫应答的方法，其中包括从 WT-1 蛋白提取的多肽。
• Method of producing thin enzyme-based sensing layers on planar sensors
  申请人：CALIFORNIA INSTITUTE OF TECHNOLOGY

  公开号：US11026610B2

  公开（公告）日：2021-06-08

  A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.

  通过将信号转导酶与包括缓冲盐和填料在内的非反应性成分混合，并将酶旋涂到基底上，制造出一种植入组织并包括传感层的传感器。将涂层基底引入真空室后，信号传导酶会发生交联。在真空室中，交联剂蒸发并沉积到酶上，从而使酶交联。