(S)-3-phenyl-2-{4-[2,2,2-trifluoro-1-(4-methoxy-benzyloxy)-1-trifluoromethyl-ethyl]-phenoxy}-propan-1-ol | 882069-87-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (S)-3-phenyl-2-{4-[2,2,2-trifluoro-1-(4-methoxy-benzyloxy)-1-trifluoromethyl-ethyl]-phenoxy}-propan-1-ol
• 英文别名: (2S)-2-[4-[1,1,1,3,3,3-hexafluoro-2-[(4-methoxyphenyl)methoxy]propan-2-yl]phenoxy]-3-phenylpropan-1-ol
• CAS: 882069-87-6
• 化学式: C₂₆H₂₄F₆O₄
• 分子量: 514.465
• InChiKey: NCZHSCYBEFPHLF-QHCPKHFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  36
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• Novel hexafluoroisopropanol substituted ether derivatives
  申请人：Dehmlow Henrietta

  公开号：US20060074115A1

  公开（公告）日：2006-04-06

  The invention is concerned with novel hexafluoroisopropanol substituted ether derivatives of formula (I): wherein R 1 to R 3 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to LXR alpha and LXR beta and can be used as medicaments.

  这项发明涉及公式（I）的新型六氟异丙醇取代醚衍生物： 其中R1至R3如描述和索赔中定义，并且其生理上可接受的盐和酯。这些化合物与LXRα和LXRβ结合，可用作药物。
• HEXAFLUOROISOPROPANOL SUBSTITUTED ETHER DERIVATIVES
  申请人：F. Hoffmann-La Roche AG

  公开号：EP1802566B1

  公开（公告）日：2008-11-26
• US7473705B2
  申请人：——

  公开号：US7473705B2

  公开（公告）日：2009-01-06
• [EN] HEXAFLUOROISOPROPANOL SUBSTITUTED ETHER DERIVATIVES<br/>[FR] DERIVES D'ETHER SUBSTITUES PAR DU HEXAFLUOROISOPROPANOL
  申请人：HOFFMANN LA ROCHE

  公开号：WO2006037480A1

  公开（公告）日：2006-04-13

  The invention is concerned with hexafluoroisopropanol substituted ether derivatives of formula (I), wherein Rl to R3 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to LXR alpha and LXR beta and can be used as medicaments.