4-[2-[N-[4-n-butoxy-2-(hydroxymethyl)phenyl]-N-methylamino]ethyl]-1-[2-(3,4-methylenedioxyphenyl)ethyl]piperidin-4-ol | 337982-12-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 4-[2-[N-[4-n-butoxy-2-(hydroxymethyl)phenyl]-N-methylamino]ethyl]-1-[2-(3,4-methylenedioxyphenyl)ethyl]piperidin-4-ol
• 英文别名: 1-[2-(1,3-benzodioxol-5-yl)ethyl]-4-[2-[4-butoxy-2-(hydroxymethyl)-N-methylanilino]ethyl]piperidin-4-ol
• CAS: 337982-12-4
• 化学式: C₂₈H₄₀N₂O₅
• 分子量: 484.636
• InChiKey: BENNFRHQGIXCDW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  35
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  4-[2-[N-[4-n-butoxy-2-(hydroxymethyl)phenyl]-N-methylamino]ethyl]-1-[2-(3,4-methylenedioxyphenyl)ethyl]piperidin-4-ol 在 盐酸 作用下， 以 甲醇 为溶剂， 生成 4-[2-[N-[4-n-butoxy-2-(hydroxymethyl)phenyl]-N-methylamino]ethyl]-1-[2-(3,4-methylenedioxyphenyl)ethyl]piperidin-4-ol dihydrochloride
  参考文献：
  名称：

  EP1182192

  摘要：

  公开号：
• 作为产物：
  描述：

  N-[4-n-butoxy-2-(hydroxymethyl)phenyl]-N-methyl-2-[4-hydroxy-1-[(3,4-methylenedioxyphenyl)acetyl]piperidin-4-yl]acetamide 在 盐酸 、 甲醇 、 dimethyl sulfide borane 作用下， 以 四氢呋喃 为溶剂， 以1.02 g的产率得到4-[2-[N-[4-n-butoxy-2-(hydroxymethyl)phenyl]-N-methylamino]ethyl]-1-[2-(3,4-methylenedioxyphenyl)ethyl]piperidin-4-ol
  参考文献：
  名称：

  EP1182192

  摘要：

  公开号：

文献信息

• 4-hydroxypiperidine derivatives having antiarrhythmic activity
  申请人：Mochida Pharmaceutical Co., Ltd.

  公开号：US20020188006A1

  公开（公告）日：2002-12-12

  The present invention relates to a compound represented by the following formula (I) or a salt thereof, or a pharmaceutical composition containing the compound as an effective ingredient: 1 (wherein A represents, for example, phenyl group substituted with R 1 and R 2 or unsubstituted thienyl group; R 1 and R 2 each independently represent, for example, hydrogen atom, halogen atom or lower alkoxycarbonyl group; R 3 represents, for example, hydrogen atom; R 4 represents, For example, lower alkyl group; R 5 represents, for example, lower alkoxy group; R 6 represents, for example, hydrogen atom; R 7 and R 8 each represent, for example, hydrogen atom, respectively; X represents, for example, a single bond; Y represents, for example, methylene group or benzylidene group substituted with R 1 ; and Z represents, for example, methylene group.) The compounds according to the present invention that do not suppress the transient sodium current of the cardiac muscle and do not manifest proarrhythimic activity is useful as a therapeutic agent for preventing and/or treating arrhythimia and for preventing sudden death.

  本发明涉及以下式(I)所表示的化合物或其盐，或含有该化合物作为有效成分的药物组合物：1（其中A代表例如被R1和R2取代的苯基或未被取代的噻吩基；R1和R2各自独立地代表例如氢原子、卤素原子或低碳酸酯基；R3代表例如氢原子；R4代表例如低烷基基团；R5代表例如低烷氧基团；R6代表例如氢原子；R7和R8各自代表例如氢原子；X代表例如单键；Y代表例如被R1取代的亚甲基基团或苄亚甲基基团；以及Z代表例如亚甲基基团。）本发明的化合物不抑制心肌瞬时钠电流，也不表现出致心律失常活性，因此可用作预防和/或治疗心律不齐和预防猝死的治疗剂。
• 4-HYDROXYPIPERIDINE DERIVATIVES HAVING ANTIARRHYTHMIC EFFECT
  申请人：MOCHIDA PHARMACEUTICAL CO., LTD.

  公开号：EP1182192A1

  公开（公告）日：2002-02-27

  The present invention relates to a compound represented by the following formula (I) or a salt thereof, or a pharmaceutical composition containing the compound as an effective ingredient: (wherein A represents, for example, phenyl group substituted with R1 and R2 or unsubstituted thienyl group; R1 and R2 each independently represent, for example, hydrogen atom, halogen atom or lower alkoxycarbonyl group; R3 represents, for example, hydrogen atom; R4 represents, for example, lower alkyl group; R5 represents, for example, lower alkoxy group; R6 represents, for example, hydrogen atom; R7 and R8 each represent, for example, hydrogen atom, respectively; X represents, for example, a single bond; Y represents, for example, methylene group or benzylidene group substituted with R1; and Z represents, for example, methylene group.) The compounds according to the present invention that do not suppress the transient sodium current of the cardiac muscle and do not manifest proarrhythimic activity is useful as a therapeutic agent for preventing and/or treating arrhythimia and for preventing sudden death.

  本发明涉及下式(I)代表的化合物或其盐，或含有该化合物作为有效成分的药物组合物： (其中 A 代表例如被 R1 和 R2 取代的苯基或未取代的噻吩基；R1 和 R2 各自独立地代表例如氢原子、卤素原子或低级烷氧羰基；R3 代表例如氢原子；R4 代表例如低级烷基；R5 代表例如低级烷氧基； R6 代表例如氢原子； R7 和 R8 分别代表例如氢原子； X 代表例如单键； Y 代表例如亚甲基或被 R1 取代的亚苄基；以及 Z 代表例如亚甲基。)根据本发明的化合物不抑制心肌的瞬态钠电流，不表现出促心律失常活性，可作为预防和/或治疗心律失常和预防猝死的治疗剂。
• US6710060B2
  申请人：——

  公开号：US6710060B2

  公开（公告）日：2004-03-23