3,5-dimethyl-6H-thiazolo[4,5-d]pyrimidin-7-one-2-thione | 124724-18-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3,5-dimethyl-6H-thiazolo[4,5-d]pyrimidin-7-one-2-thione
• 英文别名: 3H-Thiazolo[4,5-d]pyrimidine-2-thione, 7-hydroxy-3,5-dimethyl-；3,5-dimethyl-2-sulfanylidene-6H-[1,3]thiazolo[4,5-d]pyrimidin-7-one
• CAS: 124724-18-1
• 化学式: C₇H₇N₃OS₂
• 分子量: 213.284
• InChiKey: UBJSDQUNZGNUDH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  盐酸乙脒 、 ethyl 4-amino-2,3-dihydro-3-methyl-2-thioxothiazole-5-carboxylate 在 sodium methylate 作用下， 以 甲醇 、 乙醇 、 水 为溶剂， 生成 3,5-dimethyl-6H-thiazolo[4,5-d]pyrimidin-7-one-2-thione
  参考文献：
  名称：

  Triazolo[1,5-c]pyrimido[1,4]azines as bronchodilators

  摘要：

  已发现1,2,4-三唑并[1,5-c]嘧啶并[1,4]-嘧啶具有强效的支气管扩张活性。此外，还有使用这些化合物诱导支气管扩张的药理学方法，含有这些化合物的制药组合物，以及用于制备这些化合物的合成中间体，包括1,2,4-三唑并[4,3-c]-嘧啶并[1,4]嘧啶。

  公开号：

  US04981850A1

文献信息

• Triazolo[1,5-c]pyrimido[1,4]-azines as bronchodilators
  申请人：Riker Laboratories, Inc.

  公开号：US05166343A1

  公开（公告）日：1992-11-24

  Substituted 1,2,4-triazolo[1,5-c]pyrimido[1,4]azines have been found to have potent bronchodilator activity. Pharmacological methods for inducing bronchodilation using such compounds, pharmaceutical compositions containing such compounds, and synthetic intermediates for preparing such compounds are also described.

  已发现替代的1,2,4-三唑并[1,5-c]嘧啶并[1,4]嗪具有强效的支气管扩张活性。本文还描述了使用这些化合物诱导支气管扩张的药理学方法，含有这些化合物的制药组合物以及制备这些化合物的合成中间体。
• Triazolo[1,5-C]pyrimido[1,4]azines as bronchodilators
  申请人：Riker Laboratories, Inc.

  公开号：US05089493A1

  公开（公告）日：1992-02-18

  Substituted 1,2,4-triazolo[1,5-c]pyrimido[1,4]-azines have been found to have potent bronchodilator activity. Pharmacological methods for inducing bronchodilation using such compounds, pharmaceutical compositions containing such compounds, and synthetic intermediates for preparing such compounds are also described.

  替代的1,2,4-三唑并[1,5-c]嘧啶并[1,4]-嗪已被发现具有强效的支气管扩张剂活性。本文还描述了使用这些化合物诱导支气管扩张的药理学方法，含有这些化合物的制剂，以及制备这些化合物的合成中间体。
• Triazolo(1,5-c)pyrimido(1,4) azines as bronchodilators
  申请人：RIKER LABORATORIES, INC.

  公开号：EP0327284B1

  公开（公告）日：1994-08-17
• Novel dipeptidyl peptidase IV inhibitors used for functionally influencing different cells and treating immunological, infammatory, neuronal, and other diseases
  申请人：Ansorge Siegfried

  公开号：US20070037785A1

  公开（公告）日：2007-02-15

  The present invention relates to substances capable of specifically inhibiting Gly-Pro-p-nitroanilide cleaving peptidases, for a use in the medical field. Furthermore, the invention relates to the use of at least one of such substances or of at least one pharmaceutical or cosmetic composition containing at least one such substance for a prophylaxis or a therapy of diseases, particularly for a prophylaxis and a therapy of diseases accompanied by an excessive immune response (autoimmune diseases, allergies, transplant rejections), of other chronic-inflammatory diseases, of neuronal diseases and cerebral damage, of skin diseases (inter alia acne, psoriasis), of tumor diseases and of specific virus infections (inter alia SARS).
• US4981850A
  申请人：——

  公开号：US4981850A

  公开（公告）日：1991-01-01