{5-[4-(5-fluoro-6-methyl-pyridin-2-yl)-benzenesulfonyl-amino]-5,6,7,8-tetrahydro-naphthalen-1-yloxy}-acetic acid | 1208101-12-5

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: {5-[4-(5-fluoro-6-methyl-pyridin-2-yl)-benzenesulfonyl-amino]-5,6,7,8-tetrahydro-naphthalen-1-yloxy}-acetic acid
• 英文别名: 2-[[5-[[4-(5-Fluoro-6-methylpyridin-2-yl)phenyl]sulfonylamino]-5,6,7,8-tetrahydronaphthalen-1-yl]oxy]acetic acid
• CAS: 1208101-12-5
• 化学式: C₂₄H₂₃FN₂O₅S
• 分子量: 470.521
• InChiKey: ALYLPGQHOAEUMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  114
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• BI-ARYL AMINOTETRALINES
  申请人：Blanc Jean-Baptiste

  公开号：US20100041714A1

  公开（公告）日：2010-02-18

  The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein R 1 -R 5 , A, B, Q, W, and X are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.

  这项发明涉及式I的化合物：及其药学上可接受的盐和酯，其中R1-R5，A，B，Q，W和X在详细描述和索赔中有定义。此外，本发明涉及制造和使用式I的化合物的方法，以及含有这种化合物的药物组合物。式I的化合物是CRTH2受体的拮抗剂，可能对治疗与该受体相关的疾病和紊乱有用，如哮喘。
• US8163781B2
  申请人：——

  公开号：US8163781B2

  公开（公告）日：2012-04-24
• [EN] BI-ARYL AMINOTETRALINES<br/>[FR] BI-ARYLE AMINOTÉTRALINES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2010018113A2

  公开（公告）日：2010-02-18

  The invention is concerned with the compounds of formula (I) and pharmaceutically acceptable salts and esters thereof, wherein R1-R5, A, B, Q, W, and X are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.