8-amino-7-oxo-7H-phenoxazine-2-carboxylic acid | 149837-40-1

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 8-amino-7-oxo-7H-phenoxazine-2-carboxylic acid
• 英文别名: 8-Amino-7-oxo-7H-phenoxazin-2-carbonsaeure；2-Aminophenoxazin-3-one-8-carboxylic acid；8-amino-7-oxophenoxazine-2-carboxylic acid
• CAS: 149837-40-1
• 化学式: C₁₃H₈N₂O₄
• 分子量: 256.218
• InChiKey: PIHXIYNNRYFAAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 potassium dichromate 、 硫酸 作用下， 生成 8-amino-7-oxo-7H-phenoxazine-2-carboxylic acid
  参考文献：
  名称：

  Diepolder, Chemische Berichte, 1896, vol. 29, p. 1758

  摘要：

  DOI：

文献信息

• METHOD FOR PRODUCING 3-ACETYLAMINO-4-HYDROXYBENZOIC ACID
  申请人：Ajinomoto Co., Inc.

  公开号：EP2857510A1

  公开（公告）日：2015-04-08

  The present invention provides a method for conveniently and efficiently producing a 3-acetylamino-4-hydroxybenzoic acid-type compound that is a stable compound by a process using a microorganism. Specifically the present invention provides a microorganism having an ability to produce 3-amino-4-hydroxybenzoic acid, that is modified so as to increase an activity to form 3-amino-4-hydroxybenzoic acid from dihydroxyacetone phosphate and aspartate semialdehyde, wherein the microorganism is modified so as to increase an N-hydroxyarylamine O-acetyltransferase (NhoA) activity, as well as a method for producing the 3-acetylamino-4-hydroxybenzoic acid-type compound using such a microorganism.

  本发明提供了一种方法，通过使用微生物的工艺，方便、高效地生产稳定的 3-乙酰氨基-4-羟基苯甲酸类化合物。具体地说，本发明提供了一种具有生产 3-氨基-4-羟基苯甲酸能力的微生物，该微生物经过改性，以提高由磷酸二羟基丙酮和天冬氨酸半醛形成 3-氨基-4-羟基苯甲酸的活性、其中对微生物进行了改造，以提高 N-羟基芳胺 O-乙酰转移酶（NhoA）的活性，以及使用这种微生物生产 3-乙酰氨基-4-羟基苯甲酸类化合物的方法。
• Processes and host cells for genome, pathway, and biomolecular engineering
  申请人：enEvolv, Inc.

  公开号：US10370654B2

  公开（公告）日：2019-08-06

  The present disclosure provides compositions and methods for genomic engineering.

  本公开提供了基因组工程的组合物和方法。
• Method for Producing 3-Acetylamino-4-Hydroxybenzoic Acid
  申请人：AJINOMOTO CO., INC.

  公开号：US20150079644A1

  公开（公告）日：2015-03-19

  The present invention provides a method for conveniently and efficiently producing a 3-acetylamino-4-hydroxybenzoic acid-type compound that is a stable compound by a process using a microorganism. Specifically the present invention provides a microorganism having an ability to produce 3-amino-4-hydroxybenzoic acid, that is modified so as to increase an activity to form 3-amino-4-hydroxybenzoic acid from dihydroxyacetone phosphate and aspartate semialdehyde, wherein the microorganism is modified so as to increase an N-hydroxyarylamine O-acetyltransferase (NhoA) activity, as well as a method for producing the 3-acetylamino-4-hydroxybenzoic acid-type compound using such a microorganism.
• PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING
  申请人：ENEVOLV, INC.

  公开号：US20160186168A1

  公开（公告）日：2016-06-30

  The present disclosure provides compositions and methods for genomic engineering.
• US9447443B2
  申请人：——

  公开号：US9447443B2

  公开（公告）日：2016-09-20