2-Butyleicosansaeure | 32815-57-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-Butyleicosansaeure
• 英文别名: 2-Butylicosanoic acid
• CAS: 32815-57-9
• 化学式: C₂₄H₄₈O₂
• 分子量: 368.644
• InChiKey: PUDFDRZTCWMRCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.8
• 重原子数：
  26
• 可旋转键数：
  21
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• NOVEL ACYL ACIDIC AMINO ACID ESTER
  申请人：SUGIMOTO Takanori

  公开号：US20120071570A1

  公开（公告）日：2012-03-22

  Provided is a novel oily material that spreads smoothly upon application and is free from stickiness, and also gives ungreasy and moisturized feeling after application, but does not give friction feeling peculiar to silicone. The invention was completed upon finding that a specific acyl acidic amino acid monosilicone monosterol ester can solve the foregoing problems.

  提供了一种新型油性材料，涂抹时能够平滑地展开，且不具有黏性，涂抹后能够给予无油腻感和保湿感，但不会产生硅胶特有的摩擦感。该发明是在发现特定的酰基酸性氨基酸单硅酮单甾醇酯能够解决上述问题之后完成的。
• Tocopherol derivatives and method for preparation thereof
  申请人：——

  公开号：US20020045765A1

  公开（公告）日：2002-04-18

  An object of the present invention is to provide the tocopherol derivatives represented by the following formula (I), and their salts: 1 Wherein, R 1 , R 2 and R 3 are H or methyl group, and at least one positions selected from group consisting of the R 1 , R 2 and R 3 positions are methyl group; and, A is CH 2 —CH(CH 3 )— or CH═C(CH 3 )— The other object of the present invention is to provide a method for preparing the above tocopherol derivatives. The tocopherol derivatives is prepared by reacting tocopherol with phosphorous oxychloride in an equivalent ratio of 1: 1˜1.3, in presence of an organic base, in an organic solvent; reacting the tocopherol dichlorophosphate produced by the above reaction with 3-aminopropanol in presence of an organic base, in an organic solvent; and, hydrolyzing the above products. The tocopherol derivatives according to the present invention can be hydrolyzed by biological enzymes in a living body to produce tocopherol and 3-aminopropane phosphate. And they can induce physiological activities including recovery of injured skin, prevention from aging of bio-membrane, etc. Also, the tocopherol derivatives according to the present invention have improved stability, safety to skin and anti-oxidant effect superior to preceding tocopherol and its derivatives.

  本发明的一个目的是提供以下式(I)所代表的生育酚衍生物及其盐：1其中，R1、R2和R3为氢或甲基基团，并且在R1、R2和R3位置中选择至少一个位置为甲基基团；而A为CH2—CH(CH3)—或CH═C( )—本发明的另一个目的是提供上述生育酚衍生物的制备方法。该生育酚衍生物是通过在有机溶剂中，在有机碱存在下，将生育酚与氧化氯化磷按1:1˜1.3的当量比反应，然后在有机碱存在下，将上述反应产生的生育酚二氯代磷酸酯与3-氨基丙醇反应，最后水解上述产物制备而成的。本发明提供的生育酚衍生物可以被生物酶在活体内水解成生育酚和3-氨基丙醇磷酸酯，并且可以诱导生理活性，包括恢复受损皮肤、预防生物膜老化等。此外，本发明的生育酚衍生物具有比先前的生育酚及其衍生物更好的稳定性、对皮肤的安全性和抗氧化效果。
• Controlled release nanoparticles for percutaneous use and composition containing the same
  申请人：PACIFIC CORPORATION

  公开号：EP1249232A1

  公开（公告）日：2002-10-16

  Disclosed herein is a percutaneous releasing material and agent having such characteristics as a high stability of the active agent in the formulation, a high topical absorption rate, decreased irritation on the skin and increased tactile comfort, and provides an external application agent composition prepared by using nanometer-sized polymer particles, i.e., 1 to 500 nm preferably 30 to 150 nm particles. Further, according to the present invention the polymer particles containing physiologically active agent penetrates through stratum corneum to the upper layer of dermis, then effuses the physiologically active agent into the skin while staying in the upper layer of dermis.

  本发明公开了一种经皮释放材料和制剂，具有制剂中活性剂的高稳定性、高局部吸收率、减少对皮肤的刺激和增加触感舒适度等特点，并提供了一种通过使用纳米级聚合物颗粒制备的外用制剂组合物，即 1 至 500 nm，优选 30 至 150 nm 的颗粒。此外，根据本发明，含有生理活性剂的聚合物颗粒可穿透角质层到达真皮上层，然后将生理活性剂渗入皮肤，同时停留在真皮上层。
• Use of tocopherol derivatives for stabilizing nano-sized emulsion particles containing lecithin and their external application to the skin
  申请人：PACIFIC CORPORATION

  公开号：EP1264595A1

  公开（公告）日：2002-12-11

  Disclosed herein is a stabilization method of nano-sized emulsion by using lecithin and tocopheryl derivatives represented by the following formula ( I ) and (wherein, R1, R2 and R3 are H or methyl group, and at least one position selected from the group consisting of the R1, R2 and R3 positions are methyl group; and, A is CH2-CH(CH3)- or CH=C(CH3)-) and an external application for skin containing the stabilized nano-sized emulsion.

  本文公开了一种利用卵磷脂和生育酚衍生物稳定纳米级乳液的方法，该卵磷脂和生育酚衍生物由下式（I）和（II）代表。 其中 R1、R2 和 R3 是 H 或甲基，从 R1、R2 和 R3 位置组成的组中选出的至少一个位置是甲基；以及 A 是 CH2-CH(CH3)- 或 CH=C( )-) 以及含有稳定纳米乳液的皮肤外用产品。
• REVERSIBLY THERMOCHROMIC COMPOSITION
  申请人：Kabushiki Kaisha Pilot Corporation

  公开号：EP2772523A1

  公开（公告）日：2014-09-03

  [Object] To provide a reversibly thermochromic composition free from accidental discoloration by heat conducting from the opposite side writing surface or by self-heating due to quick writing; and also to provide a solid writing material and a writing ink composition comprising that composition. [Means to solve the problem] A reversibly thermochromic composition comprising a combination of: (a) a reversibly thermochromic component capable of being discolored or decolored by heat and (b) a component for controlling heat conducting to the reversibly thermochromic component; and also a solid writing material and a writing ink composition comprising that composition.

  [目的]提供一种可逆热致变色组合物，该组合物不会因反面书写面的热传导或快速书写导致的自热而意外变色；还提供一种固体书写材料和包含该组合物的书写墨水组合物。 [解决问题的方法] 一种可逆热致变色组合物，由以下物质组合而成：(a) 能够受热变色或脱色的可逆热致变色成分和 (b) 用于控制热量传导至可逆热致变色成分的成分；以及包含该成分的固体书写材料和书写墨水组合物。