2'-aminothiazole-[4,5:1,2]-morphine | 1085568-94-0

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: 2'-aminothiazole-[4,5:1,2]-morphine
• CAS: 1085568-94-0
• 化学式: C₁₈H₁₉N₃O₃S
• 分子量: 357.433
• InChiKey: MXRRJTGJHPUDBU-WYVVOOFXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.39
• 重原子数：
  25.0
• 可旋转键数：
  0.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  91.84
• 氢给体数：
  3.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  2'-aminothiazole-[4,5:1,2]-morphine 在 甲烷磺酸 作用下， 反应 0.42h， 生成 9-amino-11,12-dihydroxy-6-methylthiazolo[5,4-k]-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
  参考文献：
  名称：

  Formation of novel thiazolomorphinans and thiazoloaporphines

  摘要：

  A novel strategy has been developed for the synthesis of ring A fused thiazolomorphinans and ring D fused thiazoloaporphines offering the possibility of formation of regioisomeric products. The conventional thermal thiazole-forming reaction was replaced with microwave initiation and a detailed discussion has been presented on the proposed mechanism of the ring Closure. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.08.069
• 作为产物：
  描述：

  potassium thioacyanate 、 2-氨基-17-甲基-4,5alpha-环氧-7,8-二去氢吗喃-3,6alpha-二醇 在 溴 、 溶剂黄146 作用下， 反应 0.25h， 生成 2'-aminothiazole-[4,5:1,2]-morphine
  参考文献：
  名称：

  Formation of novel thiazolomorphinans and thiazoloaporphines

  摘要：

  A novel strategy has been developed for the synthesis of ring A fused thiazolomorphinans and ring D fused thiazoloaporphines offering the possibility of formation of regioisomeric products. The conventional thermal thiazole-forming reaction was replaced with microwave initiation and a detailed discussion has been presented on the proposed mechanism of the ring Closure. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.08.069