4-[N-methyl-N-(p-vinylbenzyl)amino]pyridine | 82941-32-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[N-methyl-N-(p-vinylbenzyl)amino]pyridine
• 英文别名: N-[(4-ethenylphenyl)methyl]-N-methylpyridin-4-amine
• CAS: 82941-32-0
• 化学式: C₁₅H₁₆N₂
• 分子量: 224.305
• InChiKey: DVBRAKCTPZAELA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-甲氨基吡啶 、 4-氯甲基苯乙烯 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 26.0h， 以93%的产率得到4-[N-methyl-N-(p-vinylbenzyl)amino]pyridine
  参考文献：
  名称：

  机器辅助的SR48692流动合成：用于研究神经降压素受体-1的探针

  摘要：

  这里，我们报告Meclinertant（SR48692，的常规分批方式合成的直接比较1），神经降压素受体-1拮抗剂，以其机器辅助流动化学替代。通过使用这些辅助工具，再加上固体支持的试剂和清除剂，可以观察到许多工艺优势。但是，必须注意不要将这些技术转换为不存在的问题的昂贵解决方案。

  DOI：

  10.1002/chem.201300696

文献信息

• Bifunctional Polymeric Organocatalysts and Their Application in the Cooperative Catalysis of Morita–Baylis–Hillman Reactions
  作者：Cathy Kar-Wing Kwong、Rui Huang、Minjuan Zhang、Min Shi、Patrick H. Toy

  DOI：10.1002/chem.200601197

  日期：2007.3.5

  these polymeric reagents contained either alkyl alcohol or phenol groups on the polymer backbone. The use of these materials as organocatalysts in a range of Morita-Baylis-Hillman reactions indicated that hydroxyl groups could participate in the reactions and accelerate product formation. In the cases examined, phenol groups were more effective than alkyl alcohol groups for catalyzing the reactions

  制备了一系列可溶的，非交联的聚苯乙烯负载的三苯基膦和4-二甲基氨基吡啶试剂。这些聚合物试剂中的一些在聚合物主链上包含烷基醇或酚基。这些材料在一系列Morita-Baylis-Hillman反应中用作有机催化剂表明，羟基可参与反应并加速产物形成。在所检查的情况下，酚基比烷基醇基对催化反应更有效。本文是用于有机合成的非天然双功能聚合试剂的合成和使用的首批报道之一，其中两个官能团可以协同参与反应的催化。
• Heterogeneous Baylis–Hillman using a polystyrene-bound 4-(N-benzyl-N-methylamino)pyridine as reusable catalyst
  作者：Avelino Corma、Hermenegildo García、Antonio Leyva

  DOI：10.1039/b309117a

  日期：——

  An insoluble Merrifield type resin having 4-aminopyridine units is a suitable and reusable heterogeneous catalyst for the Baylis–Hillman coupling of aromatic aldehydes and α,β-unsaturated ketones.

  一种含有4-氨基吡啶单元的不溶性梅里菲尔德型树脂是芳香醛和α,β-不饱和酮的Baylis-Hillman偶联反应中一种合适且可重复使用的异相催化剂。
• Compartmentalization of Incompatible Polymers within Metal-Organic Frameworks towards Homogenization of Heterogeneous Hybrid Catalysts for Tandem Reactions
  作者：Jin-Hao Zhao、Yong Yang、Jin-Xin Che、Jun Zuo、Xiao-Hua Li、Yong-Zhou Hu、Xiao-Wu Dong、Liang Gao、Xin-Yuan Liu

  DOI：10.1002/chem.201801416

  日期：2018.7.11

  recyclable, and durable catalytic composites with excellent compartmentalization, so that opposing agents were spatially isolated. These synthesized hybrid catalysts exhibited excellent catalytic activity for one‐pot “wolf and lamb” reactions (deacetalization/Knoevenagel or Henry), which was attributed to their unique characteristic of having a locally homogeneous, but globally heterogeneous, structure

  通过将酸性和碱性聚合物原位聚合成金属-有机骨架，可以构建包含不兼容催化位点的新催化体系，从而形成具有优异隔室的高度多孔，可回收且耐用的催化复合材料，从而使相对的试剂在空间上得以隔离。这些合成的杂化催化剂对单锅“狼与羊肉”反应（脱缩醛/ Knoevenagel或Henry）表现出出色的催化活性，这归因于其具有局部均一但整体上为异质结构的独特特征。
• Curing catalyst for the reaction between carboxyl functional polymers and epoxy functional compounds for use in the preparation of powder coatings
  申请人：DSM N.V.

  公开号：EP0538931A2

  公开（公告）日：1993-04-28

  The invention relates to a curing catalyst for the reaction between carboxyl functional polymers and epoxy functional compound as a basis for powder coatings. The catalyst is a pyridine according to formula (I), in which: X = N, Z = (C1 -C1 0)alkyl or aryl and Y = (C1-C10)alkyl and in which Z and Y together can form a ring which, in addition to a carbon atom, can contain an oxygen atom, a sulphur atom and/or a nitrogen atom or X = N, Z = Y = (C1-C10)alkyl and P = polymer or X = and P = polymer.

  本发明涉及一种固化催化剂，用于羧基官能团聚合物和环氧官能团化合物之间的反应，作为粉末涂料的基础。 该催化剂是一种符合式 (I) 的吡啶、 其中 X = N、 Z = (C1 -C1 0)烷基或芳基，以及 Y = (C1-C10)烷基，以及 其中 Z 和 Y 可共同形成一个环，该环除包含一个碳原子外，还可包含一个氧原子、一个硫原子和/或一个氮原子 或 X = N Z = Y = (C1-C10)烷基和 P = 聚合物 或 X = 和 P = 聚合物。
• Microencapsulated Linear Polymers:  “Soluble” Heterogeneous Catalysts
  作者：Kristin E. Price、Brian P. Mason、Andrew R. Bogdan、Steven J. Broadwater、Jeremy L. Steinbacher、D. Tyler McQuade

  DOI：10.1021/ja063688+

  日期：2006.8.1

  A new strategy for supporting catalysts based on the microencapsulation of linear polymers is presented. In this paper, we present a DMAP capsule that is capable of catalyzing acylation reactions. The catalyst is compared to DMAP on cross-linked and linear polystyrene, as well as small molecule DMAP. Rapid optimization through modification of encapsulation conditions is demonstrated. The optimization provides a dynamic range of catalysis from 90 to 300% of the rate of DMAP on polystyrene.