4-甲基吡啶-2,6-二甲酸 | 37645-36-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 4-甲基吡啶-2,6-二甲酸
• 英文名称: 4-methyl-2,6-pyridinedicarboxylic acid
• 英文别名: 4-methyl-pyridine-2,6-dicarboxylic acid；4-Methyl-pyridin-2,6-dicarbonsaeure；4-Methylpyridin-2,6-dicarbonsaeure；4-Methylpyridine-2,6-dicarboxylic acid
• CAS: 37645-36-6
• 化学式: C₈H₇NO₄
• 分子量: 181.148
• InChiKey: JBEZLFAVOCTFPU-UHFFFAOYSA-N

物化性质

• 熔点：
  248 °C
• 沸点：
  460.1±45.0 °C(Predicted)
• 密度：
  1.460±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  87.5
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  4-甲基吡啶-2,6-二甲酸 生成 dimethyl 4-methylpyridine-2,6-dicarboxylate
  参考文献：
  名称：

  甲氧苄啶的代表产物和降解产物。3.（初步）沟通。关于甜菜色素甜菜碱的组成†

  摘要：

  描述了称为甜菜碱和异甜菜碱的两种甜菜碱糖苷。推导了它们的经验公式（C 19 H 18-20 O 8 N 2）和某些结构特征。葡聚糖的降解显示出吲哚和吡啶化合物。

  DOI：

  10.1002/hlca.19590420533
• 作为产物：
  描述：

  2,4,6-三甲基吡啶 在 air 、 molybdenum oxide vanadium oxide catalyst 、 水 、 双氧水 作用下， 生成 4-甲基吡啶-2,6-二甲酸
  参考文献：
  名称：

  Mathes; Sauermilch, Chemische Berichte, 1955, vol. 88, p. 1276,1281

  摘要：

  DOI：

文献信息

• [EN] IMIDAZOLIDINONE DERIVATIVES AS INHIBITORS OF PERK<br/>[FR] DÉRIVÉS D'IMIDAZOLIDINONE COMME INHIBITEURS DE PERK
  申请人：GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO 2) LTD

  公开号：WO2017046739A1

  公开（公告）日：2017-03-23

  The invention is directed to substituted imidazolidinone derivatives. Specifically, the invention is directed to compounds according to Formula I (I) wherein R1, R2, R3, R4, R5, R6, R7, X, Y1, Y2 and Z are defined herein. The compounds of the invention are inhibitors of PERK and can be useful in the treatment of cancer, pre-cancerous syndromes, as Alzheimer's disease, neuropathic pain, spinal cord injury, traumatic brain injury, ischemic stroke, stroke, Parkinson disease, diabetes, metabolic syndrome, metabolic disorders, Huntington's disease, Creutzfeldt-Jakob Disease, fatal familial insomnia, Gerstmann-Sträussler-Scheinker syndrome, and related prion diseases, amyotrophic lateral sclerosis, progressive supranuclear palsy, myocardial infarction, cardiovascular disease, inflammation, organ fibrosis, chronic and acute diseases of the liver, fatty liver disease, liver steatosis, liver fibrosis, chronic and acute diseases of the lung, lung fibrosis, chronic and acute diseases of the kidney, kidney fibrosis, chronic traumatic encephalopathy (CTE), neurodegeneration, dementias, frontotemporal dementias, tauopathies, Pick's disease, Neimann-Pick's disease, amyloidosis, cognitive impairment, atherosclerosis, ocular diseases, arrhythmias, in organ transplantation and in the transportation of organs for transplantation. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting PERK activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

  这项发明涉及取代咪唑烷酮衍生物。具体而言，该发明涉及根据式I（I）中R1、R2、R3、R4、R5、R6、R7、X、Y1、Y2和Z所定义的化合物。该发明的化合物是PERK的抑制剂，可用于治疗癌症、癌前综合征、阿尔茨海默病、神经病性疼痛、脊髓损伤、创伤性脑损伤、缺血性中风、中风、帕金森病、糖尿病、代谢综合征、代谢紊乱、亨廷顿病、克雅氏病、致命性家族性失眠、格斯特曼-施特劳斯勒-谢因克症候群及相关朊蛋白病、肌萎缩侧索硬化、进行性核上性麻痹、心肌梗死、心血管疾病、炎症、器官纤维化、肝脏慢性和急性疾病、脂肪肝病、肝脂肪变性、肝纤维化、肺部慢性和急性疾病、肺纤维化、肾脏慢性和急性疾病、肾脏纤维化、慢性创伤性脑病（CTE）、神经退行性疾病、痴呆症、额颞叶痴呆症、tau蛋白病、皮克氏病、尼曼-皮克氏病、淀粉样变性、认知障碍、动脉粥样硬化、眼部疾病、心律失常、器官移植以及器官移植用途中的运输。因此，该发明进一步涉及包含该发明化合物的药物组合物。该发明还进一步涉及使用该发明化合物或包含该发明化合物的药物组合物抑制PERK活性和治疗相关疾病的方法。
• PHOTOSENSITIVE PORPHYRIN DYES FOR DYE-SENSITIZED SOLAR CELLS
  申请人：NATIONAL CHUNG HSING UNIVERSITY

  公开号：US20160005546A1

  公开（公告）日：2016-01-07

  A photosensitive porphyrin-based dye is adapted to be used in a photoelectric converting device such as a dye-sensitized solar cell. The photosensitive porphyrin-based dye has a porphyrin center, at least one electron donor unit, at least one electron acceptor unit and an optional blocker unit wherein the units are directly connected to the porphyrin center or connected to the porphyrin center via ethynyl-bridges.

  一种基于光敏卟啉的染料被改进以在光电转换装置中使用，比如染料敏化太阳能电池。这种基于光敏卟啉的染料具有一个卟啉中心，至少一个电子给体单元，至少一个电子受体单元和一个可选的阻塞单元，其中这些单元直接连接到卟啉中心或通过乙炔桥连接到卟啉中心。
• [EN] 4-SUBSTITUTED PYRIDINE-2,6-DICARBOXYLIC ACID DERIVATIVES AND METHOD OF PREPARING SAME<br/>[FR] DÉRIVÉS D'ACIDE PYRIDINE-2,6-DICARBOXYLIQUE 4-SUBSTITUÉS ET LEUR PROCÉDÉ DE PRÉPARATION
  申请人：OKINAWA INST OF SCIENCE AND TECHNOLOGY SCHOOL CORP

  公开号：WO2016038890A1

  公开（公告）日：2016-03-17

  The present invention relates to novel 4-substituted pyridine-2,6-dicarboxylic acid derivatives, compounds of formula I, wherein R1 and R2are defined herein. The compounds of formula I are useful for making pharmaceutical compositions to treat proliferative diseases. The present invention also relates to concise methods for preparing compounds of formula I that may be performed under mild reaction conditions.

  本发明涉及新颖的4-取代吡啶-2,6-二羧酸衍生物，化合物的化学式为I，其中R1和R2如本文所定义。化合物的化学式I可用于制备用于治疗增殖性疾病的药物组合物。本发明还涉及用于制备化合物的简洁方法，该方法可在温和的反应条件下进行。
• Polysilylated Organosilane Compounds
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)

  公开号：US20150218192A1

  公开（公告）日：2015-08-06

  The invention concerns a mono- or polyfunctional polysilylated organosilane compound, and the method for preparing same.

  本发明涉及一种单官能或多官能的聚硅烷化有机硅化合物及其制备方法。
• PHOTOSENSITIVE ORGANIC DYES FOR DYE-SENSITIZED SOLAR CELLS
  申请人：NATIONAL CHUNG HSING UNIVERSITY

  公开号：US20150294797A1

  公开（公告）日：2015-10-15

  A photosensitive organic dye is adapted to be used in a photoelectric converting device such as a dye-sensitized solar cell. The photosensitive organic dye having a structural formula (I): where, Aryl 1 represents substituted or unsubstituted aryl with one or more aromatic rings, NR 2 R 3 represents a substituted electron-donating group, wherein N represents a nitrogen atom, and R 2 and R 3 independently represent identical or different substituted or unsubstituted hydrocarbon groups, L represents an optional linker unit, and A represents an electron-withdrawing group.

  一种光敏有机染料适用于光电转换装置，例如染料敏化太阳能电池。该光敏有机染料具有结构式（I）：其中，Aryl1代表一个或多个芳香环的取代或未取代的芳基，NR2R3代表一个取代的电子供体基团，其中N代表一个氮原子，R2和R3分别独立地代表相同或不同的取代或未取代的碳氢基团，L代表可选的连接单元，A代表电子吸引基团。