2-cyanomethyl-5-(tert-butyldiphenylsilyloxymethyl)benzimidazole | 917486-82-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-cyanomethyl-5-(tert-butyldiphenylsilyloxymethyl)benzimidazole
• 英文别名: 2-[6-[[tert-butyl(diphenyl)silyl]oxymethyl]-1H-benzimidazol-2-yl]acetonitrile
• CAS: 917486-82-9
• 化学式: C₂₆H₂₇N₃OSi
• 分子量: 425.605
• InChiKey: HXXXYJMJQFYJIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.71
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  61.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-(tert-butyldiphenylsilyloxymethyl)-1,2-benzenediamine 、 methyl 2-cyanoacetimidate hydrochloride 以 甲醇 为溶剂， 反应 2.0h， 以85%的产率得到2-cyanomethyl-5-(tert-butyldiphenylsilyloxymethyl)benzimidazole
  参考文献：
  名称：

  The First Synthesis of Protected 5-Hydroxymethyl-2-cyanomethylbenzimidazole

  摘要：

  Protected 5-hydroxymethyl-2-cyanomethylbenzimidazole 4 has successfully been synthesized starting from 3,4-diaminobenzoic acid 1. The benzimidazole 4 is expected to be a useful intermediate for the synthesis of new functional molecules such as drugs, agrochemicals, dyes, perfumes, and cosmetics.

  DOI：

  10.3987/com-07-11133

文献信息

• The First Synthesis of Protected 5-Hydroxymethyl-2-cyanomethylbenzimidazole
  作者：Isamu Katsuyama、Masanori Kubo

  DOI：10.3987/com-07-11133

  日期：——

  Protected 5-hydroxymethyl-2-cyanomethylbenzimidazole 4 has successfully been synthesized starting from 3,4-diaminobenzoic acid 1. The benzimidazole 4 is expected to be a useful intermediate for the synthesis of new functional molecules such as drugs, agrochemicals, dyes, perfumes, and cosmetics.